摘要
目的：探讨颈动脉内中膜增厚的危险因素及与相关炎症标记物水平的关系。方法：入选105例均行彩色多普勒检测颈动脉内中膜厚度（IMT）,根据结果分成IMT≥1.0mm组（A组）;IMT〈1.0mm组（B组）。分析两组各危险因素和炎症标记物水平的差异。结果：A组中年龄、收缩压、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白（HDL-C）、胆固醇（HDL-C）、血尿酸、脂蛋白a[Lp（a）]、超敏C反应蛋白、纤维蛋白原、高血压及血脂代谢紊乱病史较B组差异明显。Logistic多元回归分析发现,年龄和LDL-C是颈动脉内中膜增厚的独立危险因素,相对危险度为1.052（95%可信区间1~1.105）和4.682（95%可信区间2.302~9.524）,而HDL-C则与颈动脉IMT呈负相关,属保护性因素。结论：在颈动脉内中膜增厚的发生发展中除了传统的危险因素外,炎症反应也起了非常重要的作用。
Objective： To explore the relationship among the carotid intima-media thickness increasing, the risk factors and the levels of inflammatory markers. Methods： Totally one hundred and five patients were examined by B-mode ultrasound to measure intima-media thickness（IMT） of the common carotid artery. According to the results of B-mode ultrasound examination, we divided the patients into group A （carotid IMT≥1.0mm） and the group B（carotid IMT〈1.0mm）. Statistic analysis was performed about the risk factors and inflammatory marks between two groups. Results： There was significant difference in the values of age ,systolic blood pressure（SBP）,total cholesterol（TC） ,low dense lipoprotein（LDL-C） ,hight dense lipoprotein（HDL-C）,uric acid（UA） ,lipoprotein a（Lp（a）） ,high sensitive C-reactive protein（Hs-CRP） ,fibrinogen（FIB） and the incidence rate of hypertention and abnormal lipid between two groups.The result of Logistic regression analysis indicated that the ages and LDL-C were the independent risk factors. OR of age was 1.052（95%CI：1～1.105）,LDL-C was 4.682（95%CI：2.302～9.524）.HDL-C was negatively correlated with carotid IMT and was a protection factor. Conclusion： The traditional risk factors and the inflammatory reaction were strongly and closely related to the occurrence and development of the increased carotid IMT.
出处
《陕西医学杂志》
CAS
北大核心
2007年第7期810-812,816,共4页
Shaanxi Medical Journal
基金
江苏省卫生厅重大课题项目(H200213)
