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奥氮平与利培酮治疗精神分裂症对照研究 被引量:17

A comparative study of olanzapine and risperidone in treatment of schizophrenia
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摘要 目的:比较奥氮平与利培酮治疗精神分裂症的疗效和安全性。方法:将60例精神分裂症随机分两组,分别给予奥氮平与利培酮治疗8周。用阳性与阴性症状量表(PANSS)、治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:奥氮平与利培酮的疗效差异无显著性。奥氮平主要不良反应是嗜睡、体质量增加,利培酮主要是锥外系反应、失眠。结论:奥氮平与利培酮均是治疗精神分裂症安全有效的非典型抗精神病药,可根据患者的情况分别选择。 Objective: To stud7 the efficacy and safety of olanzapine and risperidone in the treatment of schizophrenia. Method:60 patients were randomly assigned to olanzapine group or risperidone group respectively for 8 weeks. The positive and negative symptom scale (PANSS) and treatment emergent symptom scale (TESS) were used to measure the efficacy and side effects. Results: There were no significant differences in the effects between two groups. The main side effects of olanzapine were drowsiness and increase of body weight, and those of resperidone were extrapyramidal side effects and insomina. Conclusion: Both olanzapine and risperidone are safe and effective atypical antipsychotics for treating schizophrenia, which can be selected on the basis of the status of the patients.
机构地区 河北省荣军医院
出处 《临床精神医学杂志》 2007年第5期335-336,共2页 Journal of Clinical Psychiatry
关键词 精神分裂症 奥氮平 利培酮 schizophrenia olanzapine risperidone
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  • 1王长虹,冯砚国,王来海.奥氮平与氯氮平治疗精神分裂症的双盲对照研究[J].上海精神医学,2002,14(3):143-145. 被引量:13
  • 2Beasley CM,Tollefson GD,Tran PV.Efficacy of Olanzapine:an overview of pivotal trials[J].J Clin Psychiatry,1997,58(Suppl 10):7-12.
  • 3Tollefson GD,Beasley CM,Tran PV,et al.Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorder:results of an international collaborative trial[J].Am J Psychiatry,1997,154:457-465.
  • 4Beasley CM,Tollefson GD,Tran PV. Safety of olanzapine[J].J Clin Psychiatry,1997,58(Suppl 10):13-17.
  • 5Haapasalo-Pesu KM,Saarijarvi S.Olanzapine induces remarkable weight gain in adolescent patients[J].Eur Child Adoles Psychiatry,2001,10:205-208.
  • 6[1]Bymaster FP,Calligaro DO,Falcone JF,et al.Radioreceptor binding profile of the atypical antipsychotic olanzapine.Neuropsychopharmacology ,1996,14:87
  • 7[2]Kapur S,Zipursky RB,Remington G,et al.Clinical and theor etical implications of 5-HT2 and D2 receptor occupancy of clozapine,risperi dole,and olanzapine in schizophreia.Am J Psychiatry,1999,156:286
  • 8[3]Arnt J,Skarsfeldt J.Do noval antipsychotics have similar pharmacological characteristics?a review of the evidence.Neuropsychopharmacolog y,1998,16:63
  • 9[4]Bymaster FP.In vivo and in vitro biochemistry of olanzap ine.J Clin Psychiatry,1997,58(suppl 10):28
  • 10[5]Tandon R,Milner K,Jibson MD.Antipsychotics from theory t o practice:integrating clinical and basic data.J Clin Psychiatry,1999,60(suppl 8 ):21

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