摘要
目的:观察奥施康定治疗中重度癌痛的疗效。方法:采用开放试验方法,对100例中重度癌痛患者进行治疗。奥施康定初始剂量10mg.12h-1,并根据疼痛缓解程度调整剂量。结果:100例中重度癌痛患者使用的奥施康定最小剂量10mg.12h-1,最大剂量40mg.12h-1;治疗效果:轻度缓解3例(3.0%),中度缓解12例(12.0%),明显缓解65例(65.0%),完全缓解20例(20.0%),中度以上疼痛缓解率97.0%。不良反应有:便秘12例,胃部不适、恶心8例,嗜睡5例,眩晕1例。结论:奥施康定治疗中重度癌痛疗效确切,有效率高,不良反应轻,现已应用于临床。
Objective：To observe the analgesic pain. Methods ：Opening experiment; 100 patients with effect of Oxycontin on moderate and severe cancer moderate and severe cancer pain were selected. Oxycontin was administered at an initial dose of 10 mg every 12 h and titrated upwards according to the extent of pain relief. Results：The lowest and highest doses administered werel0 mg·12 h^-1 and 40 mg·12 h^-1, respectively. Among the 100 patients suffering moderate and severe cancer pain, three（3.0 % ） achieved slight pain relief; 12 （ 12. 0 % ） got moderate pain relief, 65 （65.0 % ） had obvious relief and 20（20.0% ） relieved completely. The total effective rate of moderate pain relief to complete relief was 97%. The adverse drug reactions were constipation（ 12 cases）, feeling uncomfortable in stomach and nauseating （8 cases）, sleepy （5 cases） and dizzy （1 cases）. Conclusion： Oxycontin works on quickly, safely and effectively with comparatively slight adverse drug reactions in the treatment of moderate and severe cancer pain, which is now used in clinic.
出处
《中国药物依赖性杂志》
CAS
CSCD
2007年第5期347-348,362,共3页
Chinese Journal of Drug Dependence
关键词
奥施康定
癌痛
疗效观察
Oxycontin
cancer pain
curative effect
