期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PTEN与子宫内膜癌

下载PDF
导出
摘要 子宫内膜癌是女性生殖道最常见的三大恶性肿瘤之一,但其发病机制仍不十分清楚,PTEN是一个具有磷酸酶活性的抑癌基因,在多种肿瘤中均有突变,在子宫内膜癌中突变率最高。本文就PTEN与子宫内膜癌的关系加以综述。
作者 张海燕 宋静慧 柴雅琴 杨军
机构地区 包头市中心医院妇产科 内蒙古医学院附属医院妇产科
出处 《内蒙古医学杂志》 2007年第9期1094-1095,共2页 Inner Mongolia Medical Journal
关键词 子宫内膜癌 PTEN基因 抑癌基因
分类号 R711.32 [医药卫生—妇产科学]
  • 相关文献

参考文献21

  • 1Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology Med[J]. Sci Monut, 2004,10(10): 235-241.
  • 2Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies[J]. Cancer Res, 1997, 57(18):3935-3940.
  • 3Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene murated in human brain, breast, and prostate cancer[J].Science,1997,275:1943.
  • 4Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate turnout suppressor gene, MMAC1, at chromosome I Oq23.3 that is mutated in multiple advanced cancers[J]. Nature Genet, 1997, 15:356.
  • 5Li DM, Sum H, TEP1. Encoded bby a candidate tumor suppressor locus, is a protein tyrosine phosphatase regulated by trans-forming growth factor β[J]. Cancer Res, 1997, 57:2124-2129.
  • 6朱凌冬,蔡景龙,远里美.抑癌基因PTEN的研究进展[J].基础医学与临床,2005,25(8):707-711. 被引量：8
  • 7Myers MP, Stolarov JP, Eng C. PTEN, the tumor suppressor, PTEN/MMAC1, Dephosphorylates the lipid second messenger, phosphadylinositol 3,4,5, trisphos-phate[J]. J Boil Chem, 1998,273:13375-13378.
  • 8Di Dristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression[J]. Cell,2000,100:387-390.
  • 9Hopkin, K. Asurprising function for the PTEN rumor suppression[J]. Science, 1998,282:1027-1030.
  • 10Tamura M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading, and focal adhessions by tumor suppressor PTEN [J].Science,1998,280:1614-1617.

二级参考文献45

  • 1Goberdhan DC, Wilson C. PTEN: tumour suppressor, multifunctional growth regulator and more [J]. Hum Mol Genet.2003, 12 (2) :239 - 248.
  • 2Stambolic V, Tsao MS, Macpherson D, et al. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in PTEN+/- mice[J]. Cancer Res, 2000, 60(13):3605.
  • 3Suzuki A, Yamaguchi MT, Sasaki T, et al. T cell-specific loss of PTEN leads to defects in central and peripheral tolerance[J]. Immunity, 2001, 14(5):523.
  • 4Suzuki A, Kaisho T, Qhishi M, et al. Critical roles of PTEN in B cell homeostasis and immunoglobulin class switch recombination[J]. J Exp Med, 2003, 197 (5) :657.
  • 5Hagenbeek TJ, Naspetti M, Malergue F, et al. The Loss of PTEN Allows TCR (a)(β) Lineage Thymocytes to Bypass IL-7 and Pre-TCR-mediated Signaling[J]. J Exp Med, 2004, 200(7) :883 - 894.
  • 6Parsons R. Human cancer, PTEN and the PI-3 kinase pathway[J]. Semin Cell Dev Biol, 2004, 15(2) : 171 - 176.
  • 7Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway[J] . J Clin Oncol, 2004,22(14) :2954 - 2963.
  • 8Whang YE, Yuan XJ, Liu Y, et al. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor[ J]. Vitam Horm,2004, 101(4) :409 - 426.
  • 9Morrison DK. A MAPK scaffold of the Ras pathway [J]. J cell Science, 2001, 114:1609- 1612.
  • 10Weng LP, Smith WM, Brown JL, et al. PTEN inhibits insulirr stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complexformationin a breast cancer model [J]. Hum Mol Genet,2001, 10(6) :605-616.

共引文献21

内蒙古医学杂志
2007年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部