摘要
【目的】观察氯胺酮超前镇痛对甲状腺次全切除手术患者术后疼痛的影响。【方法】选择择期行甲状腺次全切除患者40例,随机分成两组,K、C组,K组患者切皮前3 min静脉注射氯胺酮1.0 mg/kg及术中持续静脉注射0.5 mg/(kg.h)至术毕;C组切皮前及术中给予相同容量生理盐水。记录术后视觉模拟评分(VAS)及观察药物不良反应。【结果】K组术后VAS疼痛评分显著性低于C组(P<0.05);两组不良反应发生率的差异无显著性(P>0.05)。【结论】氯胺酮经静脉行超前镇痛用于甲状腺次全切除手术患者,效果确切,不良反应发生率低。
[Objective] To observe the effects of preemptive analgesia with intravenous Ketamine on the postoperative pain for patients undergoing subtotal thyroidectomy. [Methods] Forty cases scheduled for selective surgery of subtotal thyroidectomy were randomly divided into two groups. In Group K, Ketamine 1.0 mg/ kg was given intravenously 3 minutes before skin incision and thereafter 0.5 mg/（kg ·h） infusion continuously until skin closure. Normal saline was used instead of Ketamine in Group C. Postoperative pain was assessed by VAS（visual analogue scale）-score at 4,8,12,24 hours after operation , while adverse effects were assessed. [Results]The VAS-score of Group K was significantly lower than that of group C （ P 〈0.05）, but adverse effects such as nausea, vomit and swirl of two groups have no significant difference （ P 〉0.05）. [Conclusion] Preemptive analgesia with intravenous Ketamine provides satisfactory relief of postoperative pain with no obvious side effects for patients undergoing subtotal thyroidectomy.
出处
《医学临床研究》
CAS
2007年第10期1692-1693,共2页
Journal of Clinical Research
