摘要
目的:研究子宫内膜间质肉瘤(endometrial stromal sarcoma,ESS)孕激素受体亚型的表达情况及其临床意义。方法:选取1997年1月-2006年9月间青岛大学医学院、青岛市第三人民医院收治的34例的子宫内膜间质肉瘤,石蜡病理切片,用免疫组化法测定孕激素受体亚型(PRA,PRB)的表达情况。结果:PRA在ESS中的阳性表达率为73.5%(25/34),其中在低度恶性子宫内膜间质肉瘤(LESS)中的阳性表达率为87.0%(20/23),显著高于在高度恶性子宫内膜间质肉瘤(HESS)中的阳性表达率45.5%(5/11)(P<0.05);强度表达亦有显著差异(P<0.01)。ESS中PRB阳性表达率为58.8%(20/34),其中在LESS中的阳性表达率为73.9%(17/23),显著高于在HESS中的阳性表达率27.2%(3/11)(P<0.05);强度表达亦有显著差异(P<0.01)。②两种亚型与ESS临床分期的关系:PRAⅠ期、Ⅱ期、Ⅲ/Ⅳ期的阳性表达率分别为94.4%、66.7%、40%,3者比较有显著差异(P<0.05);强度比较亦有显著差异(P<0.01);PRBⅠ期、Ⅱ期、Ⅲ/Ⅳ期的阳性表达率分别为83.3%、50.0%、20.0%,3者比较有显著差异(P<0.05);强度比较亦有显著差异(P<0.05)。③9例淋巴结PRA、PRB阳性表达率22.2%(2/9),分别于ESS中PRA阳性率73.5%(25/34),PRB阳性率58.8%(20/34)比较,有显著差异(P<0.05,P<0.05)。④PRA(+),PRB(+)者,无瘤存活与因瘤死亡比较,两者都存在显著差异(P<0.01)。结论:PRA、PRB的丢失与子宫内膜间质肉瘤的恶性程度增高有关;与子宫内膜间质肉瘤的侵袭和转移有关;PRA、PRB的减少可能与淋巴结转移有关;PRA(+)、PRB(+)者预后较好。
Objective：To study the progesterone receptors A and B expressions and their clinical significance in ESS, Methods： The expressions of progesterone receptors A and B were determined by immunohistochemical method in 34 cases of endometrial stromal sarcoma. Results： OThe positive rate of PRA in ESS was 73.5% （25/34）. in which LESS had a significantly higher PRA expression rate（87. 0% ） compared with HESS （45.5%）, （P〈0.05）. The positive rate of PRB in ESS was 58.80/00 （20/ 34）,in which LESS had a significantly higher PRB expression rate （73.9 % ） compared with HESS （27.2 % ）, （P〈0.05）. （2） The positive rate of PRA in Ⅰ , Ⅱ and Ⅲ/Ⅳ： were 94.4%, and 40%, respectively with significant difference（P〈0.05） ; The positive rate of PRB in Ⅰ was 83. 3%, Ⅱ was 50. 0%, Ⅲ/Ⅳ was 20. 0%, they were demonstrated significant different（ P〈 0.05）. （3）the positive expressions 22.2 % （2/9） in lomph node meastasis were demonstrated significant different compared with PRA73.5 5% （25/34）, PRB 58. 8% （20/34） in ESS（ P〈0.05; P〈0.05）, （4） in PRA and PRB positive cases, the living without sarcoma were demonstrated significant different compared with the death decause of sarcoma （P〈0. 01% ）. Conclusion：The losing of PRA and PRB is related with increasing of their malignant degree;it is also related with their invasion and metastasis. In the lymph node, PRA and PRB is expressed positive. Prognosis is better in the cases with PRA and PRB positive than that with PRA and PRB negative.
出处
《中国临床医学》
北大核心
2007年第5期702-704,共3页
Chinese Journal of Clinical Medicine
关键词
子宫内膜间质肉瘤
孕激素受体亚型
免疫组化
Endometrial stromal sarcoma
Progesterone receptor subtype
Immunohistochemical
