摘要
目的检测雌、雄激素受体(ER、PR)和MMP-1在子宫内膜异位症(EMS)患者的异位内膜和在位内膜中表达,探讨三者在子宫内膜内异症发生发展中的作用。方法采用免疫组织化学PV-9000法分别检测ER、PR和MMP-1的表达。研究组:84例EMS的异位内膜和44例在位内膜;对照组:32例子宫肌瘤者正常子宫内膜。结果异位内膜组织中ER、PR的表达明显低于正常内膜组织和在位内膜组织(P<0.01、P<0.05),而异位内膜组织中MMP-1的表达强度明显高于正常内膜组织(P<0.05);在位内膜组织ER、PR表达却明显高于正常内膜组织(P<0.05)。结论ER、PR和MMP-1在异位内膜和EMS在位内膜中的异常表达,可能与EMS的发生发展有关。
Objective To describe expression of sex hormone receptor（ER,PR） and MMP-1 in ectopic and eutopic endometrium of endometriosis.Methods The expression of ER,PR and MMP-1 in ectopic endometrium （84 cases） and eutopic endometrium（44 cases）in endometriosis as well as normal endome-trium（32 cases） were detected by PV-9000 of immunohistochemistry.Results The expression of ER and PR in ectopic endometrium were significantly lower than that in eutopic and normal endometrium（P〈0.01,P〈0.05）,But the expression of MMP-1 in ectopic endometrium were higher than that in normal endometrium（P〈0.05）.The expression of ER and PR in eutopic endometriums were significantly higher than that in normal endometrium（P〈0.05）. Conclusion The abnormal expression of ER,PR and MMP-1 in ectopic and eutopic endometrium of endometriosis could be relevant to the development and progress of endometriosis.
出处
《实用医药杂志》
2007年第7期782-784,共3页
Practical Journal of Medicine & Pharmacy
