盐敏感性原发性高血压的发病机制与肾微损伤
摘要
19世纪末原发性高血压被描述为是继发于有临床表现的肾脏疾病而出现的。Dahl等后来通过在实验模型的移植研究结果中发现,肾脏疾病是血压升高的原因,此后该发现在人体得到证实。多数的研究者认为肾脏疾病导致血压升高的机制包括了钠重吸收及分泌的改变。在流行病学及生理学的研究中此结果均得到了证实。
出处
《中国医师进修杂志(内科版)》
2007年第11期70-72,共3页
Chinese Journal of Postgraduates of Medicine
参考文献19
-
1Caulfield M, Munroe P,Pembroke J,et al. Genome-wide mapping of human loci for essential hypertension. Lancet,2003,361 (9375): 2118-2123.
-
2Province MA,Kardia SL,Ranade K,et al. A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program. Am J Hypertens, 2003,16(2) : 144-147.
-
3Johnson RJ,Titte S,Cade JR,et al. Uric acid,evolution and primitive cultures. Semin N ephrol, 2005,25 ( 1 ) : 3-8.
-
4Yusuf S,Reddy S,Ounpuu S,et al. Global burden of cardiovascular diseases:part Ⅰ:general considerations,the epidemiologic transition, risk factors, and impact of urbanization. Circulation, 2001,104 (22) : 2746-2753.
-
5Fields LE, Burr VL,Cufler JA,et al. The burden of adult hypertension in the United States 1999 to 2000:a rising tide. Hypertension, 2004,44(4):398-404.
-
6Hughson M,Farris AB 3rd,Douglas-Denton R,et aL Glomerular number and size in autopsy kidneys:the relationship to birth weight. Kidney Int, 2003,63(6) : 2113-2122.
-
7Woods LL,Weeks DA,Rasch R. Programming of adult blood pressure by maternal protein restriction:role of nephrogenesis. Kidney Int, 2004,65(4): 1339-1348.
-
8Keller J,Zimmer G,Mall G,et al. Nephron number in patients with p finmry hypertension. N Engl J Med, 2003,348(2) : 101-118.
-
9Goldfarb DA, Metin SF, Braun WE,et al. Renal outcome 25 years after donor nephrectomy. J Urol, 2001,166(6) :2043-2047.
-
10Falkner B,Hulman S,Kushner H. Effect of birth weight on blood pressure and body size in early adolescence. Hypertension,2004,43 ( 2 ) : 203-207.
-
1高迎春,武云涛,王玲.射频消融前后TnI、CK-MB检测的变化[J].实用心电学杂志,2003,12(4):277-277.
-
2世界上最早发现受艾滋病危害的是同性恋者[J].家庭医学(上半月),1996,0(8):43-43.
-
3徐裕成.高效能便携式气胸恒定负压吸引引流装置及防脱微损伤性引流管的研究[J].现代医学仪器与应用,1998,10(1):31-32.
-
4吴帆,陈绍宇,刘宗芳.PCI术对不稳定型心绞痛患者C-反应蛋白及心肌坏死标记物的影响[J].中国现代药物应用,2008,2(19):70-71.
-
5郝翠平.冠心病介入治疗心机微损伤的临床研究[J].中国实用医药,2013,8(19):148-149.
-
6张玉海,戴如春,肖洁,陈道雄,廖二元.甲基泼尼松龙对大鼠尺骨骨量、微结构及微损伤的影响[J].中南大学学报(医学版),2015,40(1):25-30. 被引量:1
-
7丁辉(综述),蔡后荣(审校).上皮间充质转化与特发性肺纤维化的研究进展[J].医学临床研究,2010,27(1):175-179. 被引量:2
-
8王志红,郭坤元,李玉华,吴秉毅,黄睿,张超凤,蒋玲.大鼠骨髓间充质干细胞对D-半乳糖致衰老大鼠骨质的影响[J].中国老年学杂志,2011,31(8):1376-1379.
-
9张立兴,吴希瑞.胫骨平台骨折的治疗进展[J].实用骨科杂志,2005,11(3):239-242. 被引量:28
-
10谭敦勇,陈小琳,董军,C.Caramelo.诱导型一氧化氮合酶与Dahl-盐敏感大鼠动脉血压的调节(英文)[J].中国病理生理杂志,2000,16(3):207-210. 被引量:3