摘要
目的:研究电针对急性脑梗死大鼠血浆组织型纤溶酶原激活物(t-PA)及纤溶酶原激活物抑制物-1(PAI-1)含量的影响。方法:40只SD大鼠随机分为正常组、假手术组、模型组及电针组各10只,模型组及电针组大鼠制成脑梗死模型;假手术组手术步骤同前2组,但不线栓;正常组不作任何处理。造模成功后,4组大鼠均同步喂养,电针组大鼠于造模成功后即刻给予电针百会、水沟穴,每天1次,30min。治疗5d后,4组大鼠均采用ELISA法检测血浆t-PA及PAI-1含量。结果:与正常组及假手术组比较,模型组及电针组大鼠血浆t-PA、PAI-1含量均显著升高(P<0.01),但电针组低于模型组(P<0.05,0.01)。结论:电针能显著降低急性脑梗死大鼠血浆t-PA、PAI-1含量,调节机体纤溶系统活性,改善梗死区域的血液循环,促进功能恢复。
Objective： To observe the influence of electro acupuncture on the contents of plasma t-PA and PAI-1 in acute cerebral infarction rats. Methods： Forty rats were randomly divided into 4 groups, common, sham operated, model and electro acupuncture group （n--10 in each group）. The contents of plasma t-PA and PAl 1 in each group were detect ed by enzyme linked immunosorbent assay. Results： Compared with common and sham operated groups, the contents of plasma t-PA and PAl 1 in model group were significantly increased （P〈0.01）. After treatment with electro-acupunc ture, the contents of plasma t PA and PAI-1 in model group were decreased, and there was significant difference between model and electro-acupuncture group （P〈 0. 05,0. 01）. Conclusion： Electro-acupuncture can significantly decrease the contents of plasma t-PA and PAl 1 in rats with acute cerebral infarction rats, and improve the activity of fibrolysis system.
出处
《中国康复》
2007年第5期300-302,共3页
Chinese Journal of Rehabilitation
基金
湖北省教育厅科学研究计划项目(D200516006)
湖北中医学院院级课题
