摘要
目的探讨核因子-κB(NF-κB)、转化生长因子β1(TGF-β1)在椎间盘退变组织中的表达及意义。方法分别采用免疫组化法、酶联免疫吸附法检测30例退变椎间盘组织(病变组)中NF-κB、TGF-β1表达,并与10例正常椎间盘组织(对照组)比较。结果病变组椎间盘组织NF-κB、TGF-β1的表达明显高于对照组,P<0.05。结论结论NF-κB、TGF-β1可能在椎间盘组织退变中起重要作用。
[ Objective] To study the expression and significance of nuclear factor kappa B（NF-κB） and transforming growth factor β1 （TGF-131 ） in the degenerated lumbar intervertebral disc. [ Methods] Totally 30 cases of degenerated lumbar intervertebral disc tissues were obtained by surgical operation from 2004 to 2006 as lesions group, immunohistochemistry and ELISA were used to test the expression of NF-κB and TGF-13L. And the tissues of normal intervertebral disc tissues were obtained from 10 patients as control group. [ Results ] The expression of NF-κB and TGF-131 in the lesions group was higher than that in the control group（ P 〈 0.05 ）. [ Conclusion] NF-κB and TGF-β1 might play a key role in the degenerated lumbar intervertebral disc.
出处
《山东医药》
CAS
北大核心
2007年第29期13-14,共2页
Shandong Medical Journal
基金
河北省科技厅资助项目(052761422)
关键词
核因子-ΚB
转化生长因子Β1
椎间盘退变
nuclear factor kappa B
transforming growth factor β
intervertebral disc degeneration
