摘要
目的:观察PINCH蛋白在口腔鳞状细胞癌中的表达情况,探讨其临床病理意义。方法:采用免疫组织化学ABC法,检测20例正常口腔粘膜和57例口腔鳞状细胞癌石蜡存档标本中PINCH蛋白的表达情况,分析其与患者临床病理特征的关系。结果:PINCH蛋白在正常口腔粘膜中少量表达,而在口腔鳞状细胞癌中的表达明显增加,尤其是在肿瘤的浸润边缘,二者比较有显著性差异(P=0.02);在口腔鳞状细胞癌中,淋巴结转移组阳性表达率为46.2%(12/26),淋巴结无转移组阳性表达率为29.0%(9/31),二者比较有显著性差异(P=0.02);PINCH蛋白的表达与患者性别、年龄、肿瘤大小、部位和分化程度无相关性(P>0.05)。结论:PINCH蛋白在口腔鳞状细胞癌的发生、发展中可能起着重要作用,并可作为一个预测肿瘤转移的新备选分子生物学指标。同时由于其表达在间质,为与肿瘤间质有关的抗肿瘤药物的开发提供了新思路和治疗靶点。
Objective： To study PINCH protein expression in oral squamous cell carcinoma and its clinicopathological significance. Methods： ABC immunohistochemical method was used to investigate the expression of PINCH in paraffin blocks of 20 normal oral mucous tissues and 57 oral squamous cell carcinoma （SCC） tissues. The relationship between the expression of PINCH and the patients＇ clinical variables was analyzed. Results： Immunostaining of PINCH showed low expression of the protein in normal oral mucous tissue and higher expression in oral SCC, especially at the edge of invasive tissue. The statistical difference was significant（P〈0.05）. The positive rate of PINCH expression in the lymph node metastasis group and the non-metastasis group was 46.15%（12/26） and 29.32% （9/31）, respectively（P〈0.05）. PINCH expression was not correlated with gender, age, differentiation, location or tumor size. Conclusion： PINCH may play an important role in the tumorigenesis and development of oral SCC. PINCH protein may be a new biological marker of metastasis of OSCC. These results suggest a new strategy for cancer treatment.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第20期1157-1159,共3页
Chinese Journal of Clinical Oncology
基金
河北省科技攻关计划基金资助(编号:052761632)
