摘要
目的观察三氧化二砷(As2O3)及全反式维甲酸(ATRA)治疗急性早幼粒细胞白血病(APL)93例,进行临床疗效对比分析。方法观察用As2O3方案(45例)和用ATRA方案(48例)治疗APL的缓解率,无病生存期及其毒副作用。结果三氧化二砷(As2O3)组共45人,共有41例获CR,完全缓解率分别为91.1%,5年后死亡29人,生存16人,存活率为35.6%;平均生存时间为46.80月,标准误为2.03,95%可信区间为42.83～50.77月。全反式维甲酸(ATRA)组共48人,共有43例获CR,完全缓解率分别为89.6%,5年后死亡32人,生存16人,存活率为33.3%;平均生存时间为46.48月,标准误为2.00,95%可信区间为42.56～50.40月。两组缓解率及无病生存期差异亦无显著性(P>0.05),但As2O3治疗剂量的毒副作用小,均为可逆性。结论As2O3能诱导细胞凋亡,与ATRA无交叉耐药性,对治疗APL有良好疗效,且应用安全的一种诱导分化剂。
Objective To analyze As2O3 and ATRA clinical effects by using them to treat APL. Methods By studying the APL＇s relief rate,non-disease survival period after being treated with As2O3 scheme（45cases）or ATRA scheme（48cases）and their toxic and side reaction. Results 45 people had As2O3, 41 got CR, 91.1% completely alleviated the rate to distinguish, 5 died after years, 16 people existed, of the survival rate was 35. 56%; the average existence was 46. 80, the standard mistake was 2.03,95%, the zone as 42.83-50. 77, 43 got CR, the alleviating rate was 89.6%, 32 people died after 5 years,16 peoples existed, the survival rate was 33.33 %. There was no distinct difference between the relief period and survival period （P 〉 0. 05）, but the therapeutic dose of AszO3 was less toxic and reversible. Conclusions As2O3 is an excellent drug to treat APL which can induce apoptosis without cross drug resistance and can be safely used as an induction differentiation agent.
出处
《齐齐哈尔医学院学报》
2007年第18期2177-2179,共3页
Journal of Qiqihar Medical University
