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HPLC法测定氨咖黄敏胶囊中对乙酰氨基酚、咖啡因、马来酸氯苯那敏的含量 被引量:7

Determination the Contents of Paracetamol,Caffeine and Chlorphenamine Maleate in Ankahuangmin Capsule by HPLC
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摘要 目的:建立HPLC法测定氨咖黄敏胶囊中对乙酰氨基酚、咖啡因和马来酸氯苯那敏的含量;方法:色谱柱:Kromasil苯基柱(250 mm×4.6 mm,5μm);流动相:乙腈-水-三乙氨(20:79:1)(磷酸调pH至3.1),检测波长为260 nm;结果:线性范围:对乙酰氨基酚15.13~35.30μg,r=0.9999;咖啡因0.911~2.11μg,r=1.0000;马来酸氯苯那敏0.06~0.15μg,r= 0.9998;平均回收率:对乙酰氨基酚99.5%,RSD%=0.5%;咖啡因100.0%,RSD%=0.3%;马来酸氯苯那敏99.6%,RSD%=0.9%。结论:本方法简便、准确、灵敏度高、重现性好,可更好地控制本品质量。 Objective: To establish a method for the determination of paracetamol, caffeine and chlorphenamine maleate in Ankahuangmin capsule by HPLC. Method: The Kromasil C6H5 column (250 mm×4.6 mm ,5 μm)was used; The mobile phase consisted of acetonitrile-water-triethylamine (20: 79:1 ) (of mobile phase was adjusted pH to 3.1 with phosphoric acid). The detection wavelength was at 260 nm. Result: The linear ranges of paracetamol, caffeine and chlorphenamine maleate were at 15.13 - 35.30μg( r = 0. 999 9 ), 0.91 - 2.11 μg( r = 1. 000 0), 0.06 - 0.15 μg( r = 0.999 8 ), respectively. The average recoveries of paracetamol, caffeine and chlorphenamine maleate were 99.5% (RSD% =0.5% ), 100.0% (RSD% =0.3% ), 99.6% (RSD% =0.9% ), respectively. Conclusion: The method is simple, accurate, and reproducible,it can be used for the quality control of Ankahuangrnin capsule.
出处 《中国药师》 CAS 2007年第11期1103-1105,共3页 China Pharmacist
关键词 氨咖黄敏胶囊 对乙酰氨基酚 咖啡因 马来酸氯苯那敏 含量测定 Ankahuangmin capsule Paracetamol Caffeine Chlorphenamine maleate Content Determination
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  • 1国家药典委员会.国家药品标准化学药品地方标准上升国家标准[S].第10册.2002.96
  • 2国家药品标准[S](化学药品地方标准上升国家标准)第十四册.2002.14-21
  • 3国家药品标准[S](化学药品地方标准上升国家标准)第三册.2002.3-195

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