摘要
从2-取代-3-芳基-4-噻唑啉酮(4a～4e和5)合成了三个系列新型噻唑啉酮衍生物,即5-芳基亚甲基-4-噻唑啉酮(6a～6j),4-噻唑硫酮(7a～7e和8)和4-氰基亚胺基噻唑烷(11a～11e和12).中间体4a～4e和5由醛、胺和巯基乙酸缩合得到.所有化合物的结构均经元素分析和1HNMR确证,并且采用X射线单晶衍射分析方法测定了化合物4b的结构.初步生物活性试验结果表明,部分标题化合物具有一定的杀菌活性和促进黄瓜子叶生根活性.
Three series of new thiazolidinone derivatives, namely 5-arylidene-4-thiazolidinones （6a-6j）, 4-thiazolidinethione （7a-7e and 8） and 4-cyanoiminothiazolidine （11a-11e and 12） were synthesized from 2-substituted-3-aryl-4-thiazolidinones （4a-4e and 5）. The intermediates 4a-4e and 5 were synthesized by the condensation of aldehyde, amine and mercapto acetic acid. Their structures were characterized by elemental analysis and ^1HNMR spectra, and the structure of 4b was determined by X-ray single crystal diffraction method. The preliminary bioassay showed that some title compounds exhibited certain fungicidal activities and promoting cucumber cotyledon root-formation activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2007年第11期1374-1380,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学青年基金(No.20202003)
'973'(No.2003CB114406)资助项目
