摘要
[目的]探讨经皮穿刺氩氦刀冷冻消融联合化疗治疗晚期非小细胞肺癌治疗效果。[方法]对253例ⅢB和Ⅳ期非小细胞肺癌患者分为两组:一组149例单纯接受经皮穿刺氩氦刀靶向冷冻消融治疗,另一组104例氩氦刀冷冻消融联合紫杉醇加卡铂化疗,以胸部CT动态观察治疗前后的变化,随访患者生存时间。[结果]两组手术后即刻冰球覆盖肿瘤面积分别为92%和94%。术后1个月左右CT影像变化,两组之间无显著性差异(P>0.05);术后3个月,联合治疗组CT检查结果临床受益率高于单纯冷冻组。两组中位生存时间分别为10.08±1.02个月和15.10±3.84个月,差异有显著性(P<0.01)。[结论]CT引导下经皮穿刺氩氦刀冷冻消融联合化疗治疗晚期非小细胞肺癌的疗效优于单纯氩氦刀冷冻消融治疗。
[Purpose]To investigate the efficecy of cryosurgery combined chemotherapy for advanced non-small cell lung cancer. [Methods] A total of 253 cases of IlIB and IV stage non-small cell lung cancer patients were randomly separated into two groups.The first group patients underwent cryosurgery alone and the second group patients underwent chemotherapy after cryosurgery. The chest CT, and survival time were observed at different stages after cryotherapy. [Results] There was no differences between the two groups in ice ball median surface coverage to tumor （92% vs. 94%）. CT scan showed that the same clinical benefit received at one month after cryosurgery by two groups but the differences at three months. The overall survival time of combination therapy group was 15.10±3.84 months and the only cryosurgery group was 10.08±1.02 months. There was significant difference in the two groups. [Conclusion ] Percutaneous cryosurgery plus system chemotherapy for advanced non-small cell lung cancer is more effective than cryosurgery alone.
出处
《中国肿瘤》
CAS
2007年第11期898-901,共4页
China Cancer
基金
全军"十一五"医药卫生科研项目(06MB021)
关键词
氩氦刀
冷冻消融
非小细胞肺癌
cryocare surgical system
cryotherapeutic ablation
non-small cell lung cancer
