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派罗欣联合利巴韦林治疗慢性丙型肝炎的近期疗效观察 被引量:1

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摘要 目的∶研究对丙型肝炎病毒(HCV)感染的慢性丙型肝炎患者,应用派罗欣联合利巴韦林治疗后的疗效。方法:派罗欣(聚乙二醇干扰素α-2a,PEG-IFN-α2a,罗氏)180μg,每周腹部皮下注射一次,利巴韦林(RBV)800mg/d口服,疗程48周。结果:慢性丙型肝炎患者经应用派罗欣联合利巴韦林治疗1疗程后,丙型肝炎病毒基因检测(HCV-RNA)由阳性转为阴性,血生化检测丙氨酸氨基转移酶(ALT)、谷氨酸氨基转移酶(AST)由升高恢复至正常范围。结论:慢性丙型肝炎患者,经派罗欣系统治疗后,收到了良好的近期疗效。
作者 王咏冬
出处 《吉林医学》 CAS 2007年第13期1482-1483,共2页 Jilin Medical Journal
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  • 1Strader DB,Wright T,Thomas DL,et al.Diagnosis,management,and treatment of hepatitis[J].Hepatology,2004,39:1147.
  • 2程勇前,聂青和,周永兴.丙型肝炎病毒母婴传播机制研究[J].世界华人消化杂志,2002,10(4):445-447. 被引量:17
  • 3中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量:14013
  • 4丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:735
  • 5Zeuzem S.Clinical implications of hepatitis C viral kinetics[J].J Hepatol,1991,31(Suppl):61.
  • 6Neumann AU,Lam NP,Dahari H,et al.Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy[J].Science,1998,282:103.
  • 7Wang YS,Youngster S,Bausch J,et al.Identification of the major positional isomer of pegylated interferon alpha -2b[J].Biochemistry,2000,39:10634.
  • 8Monkarsh SP,Ma Y,Aglione A,et al.Positional isomers of monopegylated interferon alpha-2a:isolation,characterization,and biological activity[J].Anal Biochem,1997,247:434.
  • 9Heathcote EJ,Shiftman ML,Cooksley WG,et al.Peginterferon alfa-2a in patients with chronic hepatitis with chronic hepatitis C and cirrhosis[J].N Eng J Med,2000,343:1673.

二级参考文献33

  • 1Zhi-Qiang Song~1 Fei Hao~1 Feng Min~2 Qiao-Yu Ma~2 Guo-Dong Liu~2 Department of Dermatology~1Department of Infectious Diseases~2,Southwest Hospital,Third Military Medical University,Chongqing 400038,China.Hepatitis C virus infection of human hepatoma cell line 7721 in vitro[J].World Journal of Gastroenterology,2001,7(5):685-689. 被引量:26
  • 2Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non- responders to interferon monotherapy: a meta- analysis of individual patient data[ J ]. Gut, 2002,51:864-869.
  • 3Papatheodoridis GV, Papadimitropoulos VC, Hsdziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus- reated cirrhosis: a meta- analysis[J] .Aliment Pnarmaool Ther, 2001,15:689- 698.
  • 4Kjaergard LL, Krogsgaard K, Gluud C. Interfern alfa with or without ribavirin for chronic hepatitis C: systematic review of randonmised trials[J].BMJ, 2001,323:1151 - 1155.
  • 5Alberti A, Benvegnu L. Management of hepatitis[J] .J Hepatol, 2003,38(Suppl1): S1014 - S1 18.
  • 6Poynard T, MdHutchison J, Davis GL, et al. Impact of interferon alfa - 2b and ribavirin on progression of liver fibrosiis in patients with chronic hepatitis C[J].Hepatology, 2000,32:1131 - 1137.
  • 7Booth JCL, O' Grady J, Neuberger J. Clinical guidelines on the mangement of hepatitis C[J]. Gut, 2001, 49(Suppl I ): il - i12.
  • 8Chander G, Sulkowski MS, Jenckes MW, et al. Treatment of chronic hepatitis C: a systemic review[J]. Hepatology, 2002, 36(5 Suppl 1 ):S135 - S144.
  • 9Di Ciomm no V, Russo P, Rava L, etal. Interferon alpha in the treatment of chronic hepatitis C in children: a mmeta- analysis[J] .J Viral Hepat,2003,10:210 - 214.
  • 10Fabrizi F, Dulai G, DixitV, et al. Meta- analysis: interfeorn for the treatment of chronic hepatitis C in dialysis patients[J] .Aliment Phamacol Ther, 2003,18:1071 - 1081.

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