摘要
目的探讨复方甘草甜素对抗结核治疗的药物性肝炎的预防作用。方法采用前瞻性研究,对168例住院的肺结核患者随机分为治疗组和对照组,前者予复方甘草甜素和抗结核药物联合治疗,后者进行常规抗结核治疗,观察药物性肝炎的发生情况。结果加用复方甘草甜素后,84例肺结核患者发生药物性肝炎2例,病情轻,而对照组发生药物性肝炎12例,重症1例,发生率分别为2．4％和14．3％,其中10例药物性肝炎发生于强化期,表现为乏力、恶心、呕吐、纳差、黄疸、腹胀、肝痛等。结论复方甘草甜素可有效预防抗结核治疗的药物性肝炎。
Objective To study the preventive effect of glycyrrhizin on the hepatitis resulted from anti-tuberculous drugs. Methods Prospective study was adopted. One hundred and sixty-eight inpatients with pulmonary tuberculosis were randomly divided into treatment group and control group. The former was treated with glycyrrhizin combining with anti-tuberculous drugs, while the latter was treated with routine anti-tuberculous drugs. The occurrence of the hepatitis suffered from anti-tuberculous drugs was observed. Results Two of 84 eases in the treatment group were suffered from the hepatitis,whose state were not severe. Otherwise, 12 of 84 eases in the control group were suffered from the hepatitis, in which one ease had severe state. The incidence of hepatitis from anti-tuberculous drugs in the two groups was 2.4 % and 14.3 %, respectively. The hepatitis in ten inpatients occurred during the enhanced anti-tuberculous period, which the clinical manifestations were tiredness, nausea, vomit, icterus, windy feeling, pain in liver. Conclusion Glycyrrhizin might play a role in the prevention from anti-tuberculous drugs＇ hepatitis.
出处
《中国防痨杂志》
CAS
2007年第1期19-21,共3页
Chinese Journal of Antituberculosis
基金
福建省青年科技人才创新项目资金资助(2005J081)
关键词
结核
肺
抗结核药
肝炎
复方甘草甜素
Pulmonary tuberculosis
Anti-tuberculous drug
Hepatitis
Glycyrrhizin
