摘要
目的探讨肝细胞癌组织内血供类型及其对治疗中的指导意义。方法采用Seldinger技术对200例肝细胞癌(HCC)患者肝动脉行DSA检查,并对造影资料进行分析研究,根据供血动脉在瘤体内的分布情况进行分型,根据血供类型进行治疗。结果HCC的血供分为4种类型,即肝动脉瘘型、多血供型、中血供型、少血供型。对其中100例根据4种不同的血供类型采用不同介入治疗方法。①肝动脉瘘型:采用明胶海绵或弹簧圈封堵瘘口,灌注小剂量化疗药物后用超液化碘油栓塞(TACE),联合经皮—肝穿刺瘤体内注射无水乙醇(PEI);②多血供型:经肝动脉行TACE联合PEI;③中血供型:经肝动脉灌注细胞因子诱导的杀伤细胞(CIK)联合超液化碘油(UFL)栓塞及PEI;④少血供型:经肝动脉灌注CIK联合PEI。显效率分别为31.3%、54.1%、38.9%、44.8%,总有效率为76%。结论对HCC患者根据不同的血供类型采用不同的介入治疗术式,可以弥补单一治疗方法的不足,可增强抗癌效果,改善患者的生存质量,延长患者的生存期。
[ Objective ] To explore blood supply types in hepatocellular carcinoma tissue and the clinical significance. [ Methods] The blood supply types of 200 cases of primary hepatocellular carcinoma were observed and analyzed by the distribution of supplying arteries and the artery morphology in cancer tissues. [ Results] Four kinds of blood supply types were found in cancer tissues, which were hepatic artery fistula type, rich blood supply type, common blood supply type, poor blood supply type. According to different blood supply types of 100 cases hepatocellular carcinoma patients were treated with different interventional therapy means. Pationts of hepatic artery fistula anatomy type were treated by enveloping fistula ,transcatheter arterial chemoembolization and percutaneous ethanol injection;rich blood supply type patients were transcatheter arterial chemoembolization and percutaneous ethanol injection; common blood supply type patients were treatedy transcatheter arterial affusing andcytokine-induced killer cell, ultra-fluid lipiodol embolization and pereutaneous ethanol injection; poor blood supply type patients were treate by tianscatheter arterial affusing cytokine-induced killer cell and percutaneous ethanol injection. The effective rates were 31.3% , 54. 1%, 38.9% , 44. 8% respectively, and the total effective rate was 76% （study group 100cases）. [ Conclusions] Hepatocellular carcinoma patients can be treated by different interventional therapy means according to different blood supply types, it can off sef single treatment method, enhance the anti-cancer effect, improve patient survival quantity and prolong survival time of patients.
出处
《山东医药》
CAS
北大核心
2007年第30期17-19,共3页
Shandong Medical Journal
基金
全军医药卫生科研基金重点项目(06Z18)
关键词
肝肿瘤
肝癌
血液供应
数字减影血管造影
介入疗法
Hepatocellular carcinoma
Blood.supply
Digital subtraction angiography
Intervetional therapy means
