摘要
目的探讨幽门螺杆菌(Hp)长期感染及根除与胃黏膜炎症和肠上皮化生(IM)的关系。方法随访142例4年前和156例7年前Hp感染者,分析对比其前后Hp感染情况、胃黏膜炎症和IM的变化。结果4年前Hp阳性142例中,现在104例(73.2%)Hp仍呈阳性,38例(26.8%)转阴。7年前Hp阳性的156例中,现在118例(75.6%)Hp仍呈阳性,38例(24.4%)转阴。Hp长期阳性者4年前和现在及7年前和现在的慢性炎症严重程度积分分别为1.635±0.376与1.808±0.301(P>0.05)和1.661±0.398与2.232±0.335(P<0.01);IM发生率分别为17.3%(18/104)与26.9%(28/104)(P>0.05)和11.9%(14/118)与39.0%(46/118)(P<0.01);IM严重程度积分分别为1.444±0.527与1.667±0.442(P>0.05)和1.571±0.534与2.286±0.488(P<0.05)。Hp转阴者4年前和现在及7年前和现在的慢性炎症严重程度积分分别为1.684±0.369与1.367±0.426(P<0.05)和1.647±0.389与1.182±0.396(P<0.01);IM的发生率为31.6%(12/38)和52.6%(20/38);IM严重程度积分分别为1.333±0.516与1.167±0.775(P>0.05)和1.600±0.516与1.100±0.316(P<0.05)。结论Hp感染持续时间越长,胃黏膜炎症越严重,可能IM程度亦越严重,且发生率高;根除Hp不仅能减轻胃黏膜的炎症程度和IM程度,也可能防止IM的发生。
Objective To study the effect of both long-term or after eradication of Helicobacter pylori （Hp） infection on gastric mucosa inflammation and intestinal metaplasia（IM）. Method 142 cases of Hp infection for four years and 156 cases for seven years were analyzed by contrasting the changes of Hp infection, gastric mucosa inflammation and IM. Result 38 out of 142 Hp infection reversed （26.8%） after 4 years, while 104 cases still positive （73.2%）. And 38 out of 156 Hp infection reversed （24. 4% ） after 7 years, while 118 cases still positive （75.6%）. Comparing with 4 or 7 years before and now, in Hp infection group the scores of chronic inflammation were 1. 635 ±0. 376,1. 808 ±0. 301（P 〉0. 05） and 1. 661 ±0. 398,2. 232 ±0. 335（P 〈0. 01） ;the IM incidence were 17.3 % （18/104）, 26. 9% （ 28/104 ）, （ P 〉 0. 05 ） and 11.9% （ 14/118 ）, 39. 0% （46/ 118 ）, （P 〈 0. 01 ） ; the scores of IM extent were 1. 444 ± 0. 527,1. 667 ± 0. 442 （ P 〉 0. 05 ） and 1. 571 ± 0. 534,2. 286 ± 0. 488 （P 〈 0. 05 ） respectively. In Hp reversed group the scores of chronic inflammation were 1. 684 ±0. 369,1. 182 ±0. 369（P 〈0. 01） ; the scores of IM extent were 1. 333 ±0. 516,1. 167 ±0. 775（P 〉 0. 05）and 1. 600 ± 0. 516,1. 100 ± 0. 316 （P 〈 0.05） ; the IM incidence were the same 31.6% （ 12/38 ）and 52. 6% （20/38）respectively. Conclusion The longer the Hp infection, the more severity the gastric mucosa inflammation and the same relationship existed between the extent and incidence of IM. After eradication of Hp not only the extent of inflammation and IM in gastric mucosa can be alleviated, but also the occurrence of IM be prevented.
出处
《寄生虫病与感染性疾病》
CAS
2007年第4期179-181,共3页
Parasitoses and Infectious Diseases
关键词
螺杆菌
幽门
长期感染
胃炎
肠上皮化生
Hlicobacter pylori
long-term infection
gastritis
intestinal metaplasia
