摘要
以抗癌药物多柔比星为模型药物,通过反相乳液聚合法制备了以聚乙烯吡咯烷酮为载体的多柔比星纳米颗粒,并用扫描电镜、激光粒度仪、红外光谱对其进行表征.激光粒度仪测试表明：在最佳制备条件下,纳米颗粒的平均粒径为18.8 nm,粒径分布为15-32 nm,与扫描电镜的结果基本吻合;红外光谱测试表明,制备的纳米颗粒由多柔比星和聚乙烯吡咯烷酮共同组成;体外释放研究表明,纳米粒子在体外释药缓慢.
Doxorubicin-loaded nanoparticles, using doxorubicin as model drug and polyvinylpyrrolidone as matrix material, were prepared by inverse emulsion polymerization in this paper. The property of the nanoparticles was characterized by scanning electron microscopy （SEM） , laser light scattering technique （LLS） and infrared spectrum（IR） respectively. LLS showed that the optimal prepared nanoparticles possessed an average size of 18.8 nm and a narrow size distribution between 15 and 32 nm, which was consistent with the results obtained by SEM. And IR result indicated that the nanoparticles consisted of doxorubicin and polyvinylpyrrolidone. Drug-release process of ADM-NP in vitro was slow.
出处
《福州大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第5期770-774,共5页
Journal of Fuzhou University(Natural Science Edition)
基金
福建省科技厅国际合作资助项目(2005I010
2001Z046)
关键词
多柔比星
纳米颗粒
聚乙烯吡咯烷酮
反相乳液聚合
doxorubicin
nanoparticle
polyvinylpyrrolidone
inverse emulsion polymerization
