摘要
目的:新剂型研制,制备蒿芩清胆颗粒。方法:应用正交实验筛选最佳工艺。结果:10倍水、6h提取挥发油;油∶-βCD为1∶6,恒温40℃搅拌包结挥发油1h;水提酸沉法提取黄芩苷;盐酸处理,乙酸乙酯提取青黛有效成分;8倍水、浸泡0.5h、煎煮3次、每次0.5h为最佳煎煮工艺;湿法制粒,稠膏∶糖粉∶糊精为1∶3.5∶1,必要时加72%乙醇为润湿剂。结论:所制颗粒剂符合药典要求。
Objective： To find a new modle of pharmaceutical from Haoqinqingdan decoction and make the Haoqinqingdan granule tablet. Methods： The optimum extracting and moulding process was selected by orthogonal test design. Results： The optimum extraction conditions of naphtha is 1000% water, 6 hour; The best craft of wrapping volatile oil is volatile oil：^-CD-- 1：6, mixing at constant temperature 40℃ 1 hour ; Adopt method of water-withdraw and sour-precipitate to withdraw huangqingan; Qingdai is first treated with 18% chlorhydric acid, second with ethyl acetate, soluted with 95% ethanol, and finally precipitated with O. 1% NaOH; The best decoc- tion craft is 800% water, soaking 0.5 hour, decoctions 3times, 0.5hour every time. The best craft of making granule is dense cream：sugar pouder：dextrlns = 1：3.5： 1, moulding process was made with 72% ethanol when it is nec- essary. Conclusion： The granules formulation is meeting the requirements of Pharmacopoeia.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第11期764-767,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
内蒙古自然科学基金项目(No.200208020605)
关键词
蒿芩清胆
颗粒
正交设计
制备工艺
Haoqinqingdan
Granules
Orthogonal design
Preparation technics
