摘要
目的:探讨重症监护病房患者感染的铜绿假单胞菌耐药性特点及其中医证候特点。方法:分析分离自本院重症监护病房2005年3月-2006年2月住院患者痰液标本中73株铜绿假单胞菌的体外药敏试验资料及中医证候。结果:除哌拉西林/他唑巴坦、哌拉西林、头孢哌酮/舒巴坦、阿米卡星外,73株铜绿假单胞菌对多种抗菌药物耐药。铜绿假单胞菌感染者的中医证候以虚实夹杂证及实证为主(共占97.26%),而其中虚实夹杂证以气虚痰阻证、阴虚热郁证为主,实证以痰热郁阻证、痰瘀互阻证为主。结论:对多重耐药铜绿假单胞菌感染的患者应用β-内酰胺类抗菌药和氨基糖苷类抗菌药联合治疗,同时可考虑采用中医辨证论治。
Objective： To assess the relationship between the characteristic of drug resistance in Pseudomonas aeruginosa and the syndrome of traditional Chinese medicine（TCM） in ICU. Methods： The 73 strains of Pseudomonas aeruginosa were isolated from sputum specimenpatients of in-patients in our ICU from March 2005 to February 2006. The data of the drug sensitivity test in vitro was analysised. The relation between the syndrome of TCM and drug resistance in Pseudomonas aeruginosa was probed. Results： The 73 strains of Pseudomonas aeruginosa were drug resistant to majority kinds of anti-infective except Piperacillin-Tazobactam, Piperacillin, Cefoperazone-Sulbactam, and Amikacin. The mains syndromes of TCM of all patients infected Pseudomonas aeruginosa were deficiency-excess complex（虚实夹杂证） and excess pattern（实证） （97.26%）. The mains of deficiency-excess complex（虚实夹杂证） were Qi vacuity and phlegm obstruction（气虚痰阻证）and Yin vacuity internal heat（ 阴虚热郁证）. The mains of excess pattern（实证） were phlegm-heat（痰热郁阻证）and phlegm-stasis（痰瘀互阻证）. Conclusions： Combined [3-1actam antibiotics and aminoglycoside antibiotics is the first selection to treat the muhidrugresistant Pseudomonas aeruginosa. Indentifing patterns and determining treatment in TCM could be tried in the treatment of patients infected Pseudomonas aeruginosa.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第11期808-811,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
铜绿假单胞菌
耐药性
中医证候
特点
Pseudomonas aeruginosa
drug resistance
syndrome of TCM
Characteristic
