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孕母AFP和hCG二联血清对胎儿神经管缺陷和染色体异常分析 被引量:4

Analysis neural tube defects and chromosome abnormality by detection of AFP/hCG in gravidas.
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摘要 目的探讨采用甲胎蛋白(AFP)和绒毛膜促性腺激素β亚单位(Free-βhCG)血清二联法在孕中期胎儿神经管缺陷、染色体异常出生缺陷中的作用,并进一步评价血清二联指标在产前筛查中的实用价值,增加检出率,减少假阳性及假阴性,规范检查程序,减少医疗资源浪费。方法对2004年8月至2006年4月来我院的孕妇,在知情情况下进行产前筛查,选择孕周15~20^+6周的孕妇,结合母龄、孕周、体重等因素,应用时间分辨荧光分析系统,随机分析软件计算出风险率,对高危孕妇进行羊水细胞染色体、B超等产前诊断进行确诊,接受筛查的孕妇追踪至出生。结果1020例孕中期孕妇,筛查出高危孕妇49例,阳性率为4.8%,其中唐氏高风险38例,神经管畸形高风险11例,确诊4例(脑积水1例、染色体异常2例、死胎1例),异常检出率DS为6.7%、NTD为2.5%。结论孕中期二联指标是产前筛查异常胎儿的有效指标,对出生缺陷,降低围产儿死亡率的重要手段之一,具有社会效应和实用性,值得推广应用。 Objective: To evaluate clinic value of neural tube defects (NTD) and chromosome abnormality through measuring alpha fetoprotein and ehoragon β - subunit at Mid - gestation period. Methods: To get the risk rate of the gravidas who were deeetod in our hospital from August 2004 to April 2006 by using the time - diseerment fluorescence analysis software. Results: There are 49 high risk gravidas including 11 neural tube defects ( 1 hydrocephalus, 2 chromosome abnormality and 1 fetal death) and 38 Down syndrome (DS) gravodas in 1020 gravidas at Mid - gestation. DS positive rate is 6. 7% and NTD positive rate is 2. 5%. Conclusion : AFP assoeiatod β-hCG measurement is a effectively index to prenatal screening. It can be used in clinical prenatal screening.
出处 《中国优生与遗传杂志》 2007年第11期50-52,共3页 Chinese Journal of Birth Health & Heredity
关键词 产前筛查 染色体异常 神经管缺陷 AFP Β-HCG Prenatal screening Chromosome abnormality Neural tube defects AFP β-hCG
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参考文献7

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二级参考文献7

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