摘要
目的观察独活香豆素组分(TCA)对戊巴比妥钠及巴比妥钠催眠作用的影响。方法将小鼠随机分为溶媒(5%吐温-80,20mL/kg)、氯霉素(25mg/kg)及TCA(50、100mg/kg)组,等容灌胃给药1h后,再腹腔注射戊巴比妥钠40mg/kg或巴比妥钠200mg/kg,观察催眠潜伏期和催眠时间。结果氯霉素和高、低剂量的TCA使戊巴比妥钠的催眠时间延长249.8%、171.1%和78.7%,均P<0.01;对巴比妥钠的催眠作用无明显影响。结论TCA对小鼠肝微粒体细胞色素P450具有一定的抑制作用。
Objective To observe the influence of the coumarins from Radix Angelicae pubescentis （TCA） on the hypnotic effects of pentobarbital sodium and barbital sodium. Methoda Mice were randomly divided into solvent （5% Tween-80, 20 mL/kg）, chloromycetin （25 mg/kg） and TCA （50, 100 mg/kg） groups, which were administered orally with equivalent volume. One hour later, all the animals were given pentobarbital sodium （40 mg/kg, ip） or barbital sodium （200 mg/kg, ip）, and then the latent period and duration of hypnosis were observed. Results Hypnotic duration of pentobarbital sodium was prolonged by 249.8%, 171.1% and 78.7% in chloromycetin and two TCA groups respectively （P〈0.01）, and yet hypnotic effect of barbital sodium was hardly influenced. Conclusion TCA is likely to inhibit liver microsomal cytochrome P450 activity in mice.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第11期31-32,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
独活香豆素
戊巴比妥钠
巴比妥钠
催眠作用
小鼠
coumarins from Radix Angelicae Pubescentis. pentobarbital sodium
barbital sodium
hypnotic effect
mice
