摘要
目的:探讨医用生物蛋白胶在胆囊切除手术中的应用效果。方法:选择经腹胆囊切除术患者共100例,随机分成治疗组和对照组,每组50例。手术中,治疗组胆囊床喷涂生物蛋白胶,对照组则不作此处理。对两组术后总引流量、胆瘘发生率、过敏反应、拔管时间及平均住院天数进行比较观察。结果:治疗组未发生过敏反应;治疗组术后总引流量为(75.3±7.4)mL,显著低于对照组[(99.2±9.8)mL](P<0.01)。排除术后胆囊结扎线脱落、胆总管误伤和迷走胆管瘘等原因所致的胆瘘,治疗组无胆瘘发生;对照组经再次手术证实的毛细血管渗漏4例(8%),经手术缝扎和电凝后痊愈,两组比较差异有显著性(P<0.05)。治疗组拔管时间为(23.4±3.2)h,显著低于对照组[(46.5±3.6)h](P<0.01)。治疗组平均住院天数为(13.1±1.1)d,显著低于对照组[(16.4±1.3)d](P<0.01)。结论:医用生物蛋白胶在对创面的封闭止血,预防胆瘘方面有确切的效果,且在运用过程中未发现过敏现象,值得在单纯胆囊手术中推广使用。
Objective： To investigate the feasibility of biomedical fibrin glue in cholecystectomy.Methods：One hundred patients proceeding cholecystectomy were randomly divided into two groups with 50 in each group.Biomedical fibrin glue was used in treatment group,and routine treatment was used in control group.The total volume of drainage after operation,rate of billiary fistula,allergy reaction,time of pulling out drainage tube,and average inpatient time were observed in both groups.Results：There was no allergy reaction in treatment group.Total volume of drainage in treatment group was（75.3±7.4）mL,and（99.2±9.8）mL in control group,there was a significant difference between two groups（P〈0.01）.Four billiary fistula cases in control group and none in treatment group,there was a significant difference between two groups（P〈0.05）.Time of pulling out drainage tube was（23.4±3.2）h in treatment group,and（16.4±1.3）d in control group.There was a significant difference between two groups（P〈0.01）.Average inpatient time was（13.1±1.1）d in treatment group,and（16.4±1.3）d in control group,there was a significant difference between two groups（P〈0.01）.Conclusion：Using biomedical fibrin glue has a satisfied effect on preventing billiary fistula after cholecystectomy;there was no allergy reaction and other adverse effect.
出处
《实用临床医学（江西）》
CAS
2007年第9期55-56,共2页
Practical Clinical Medicine
关键词
医用生物蛋白胶
胆道手术
胆痿
biomedical fibrin glue,cholecystectomy,billiary fistula
