摘要
为了将脑地形图技术用于豚鼠皮层慢反应（ＳＣＲ）的研究，在１０只豚鼠颅骨表面钻１４个直径为１ｍｍ的洞，放置硬膜外电极，１３导联同时记录皮层慢反应，作出彩色地形图。结果显示皮层慢反应在颞区记录到的电位比较稳定，潜伏期为３１．２５～３７．５０ｍｓ的正波（ＴＰ）与潜伏期为６２．５０～７２．５０ｍｓ的负波（ＴＮ）在颞区稳定出现，其余各导联的波都有变异。提示皮层慢反应是多源性的，部分在时间上是重叠的，而听皮层一个或更多区域对其产生起着重要作用，同时也包含有平行地来源于脑干网状丘系电活动在大脑皮层的投射，由调幅声诱发的皮层慢反应的灶位于颞区，调频声诱发的皮层慢反应的灶位于颞区和额区，说明对于声音强度的辨别，在颞区就完成了，而对于声音频率的辨别则需高级中枢的整合。
Auditory slow cortical responses (SCR) were studied in 10 awake guinea pigs using topographic mapping techniques. Fourteen electrodes were installed through the guinea pig skull and fixed with dental cement. Auditory SCRs were recorded via 13 leads and brain maps were realized on a concerto system. The results showed that SCRs were relatively stable at the temporal lobe, with a stable positivity (31.25～37.50 ms TP) followed by a negativity (62.50～72.50 ms TN). Variability was seen at other leads. The foci of maximum positivity and negativity were seen at the temporal cortex. The results suggest that there are multiple contributions to SCRs which partially overlap in time, and that auditory cortex contribute significantly more than other sources. SCRs also received auditory information in parallel from the brainstem. The focus of AM evoked SCRs was seen located at temporal lobe while that of FM evoked SCRs at temporal and frontal lobes. It suggests that intensity analysis is essentially completed at the temporal cortex whereas precise frequency discrimination relies on function of higher integrating centers.
出处
《中华耳鼻咽喉科杂志》
CSCD
1997年第3期157-159,共3页
Chinese Journal of Otorhinolaryngology
关键词
诱发反应
听觉皮质
脑地形图
Audiometry, evoked response Auditory cortex Topographic mapping
