摘要
目的：通过观察内皮素（ｅｎｄｏｔｈｅｌｉｎＥＴ）在椎动脉型颈椎病患者血浆中的变化，探讨其在该病中的病理学作用和意义。方法：用放射免疫方法分别对３０例正常人和３０例患者、２０例椎动脉减压术患者术前和术后的血浆内皮素测定。结果：椎动脉型颈椎病患者血浆ＥＴ含量（１１９．４６±５８．６５ｎｇ／ｌ）明显高于正常对照组（３８．３４±１４．３３ｎｇ／ｌ）；２０例手术患者术后ＥＴ含量（５０．８４±２１．６７ｎｇ／ｌ）明显低于术前ＥＴ含量（１３９．３４±５２．５６ｎｇ／ｌ），经统计学ｔ检验有显著性意义（Ｐ值＜０．００１）。结论：ＥＴ可能是椎动脉型颈椎病发病中的重要体液因素之一，探讨ＥＴ抗体和特异ＥＴ受体阻滞剂将为治疗该病提供新的启示。
Objective:In order to study Endothelin(ET) in the pathogenesis of vertebral arterial insufficiency type cervical spondylosis,we observed the serum ET variation in the patients with this disease. Methods:30 verterbral arterial insufficiency type cervical spondylosis patients and 30 sex and age matched healthy controls were detected seum ET levels with radioimmunoassay(RIA) . At the same time,we selected 20 severe patients for adventitia decollement operation therapy,and compared their serum ET levels pre and post operation. Results: 30 patients had higher ET levels (119.46±58.65ng/l) than that of the controls(38.43± 14.33 ng/l), and the 20 patients had higher ET levels preoperation (139.34±52.56ng/l) than the levels after operation (50.84±21.67ng/l). Both have statistical significance(P<0.01). Conclusions: The serum ET is one of the important humoral factors contributing to vertebral arterial insufficiency type cervical spondylosis. It may be useful in treating vertebral arterial insufficience type cervical spondylosis with effective ET antibody, inhibitor of ET converting enzyme and special ET receptor blocker.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1997年第6期387-388,共2页
Chinese Journal of Orthopaedics
基金
陕西省自然科学基金
关键词
颈椎病
内皮素
椎动脉
放射免疫法
Cervical spondylosis Endothelin Vertebral artery Radioimmunoassay
