摘要
目的:探讨Survivin和增殖细胞核抗原PCNA在大肠癌组织中的表达和意义。方法:采用免疫组织化学方法检测正常大肠粘膜、腺瘤和腺癌组织中Survivin和PCNA表达。结果;Survivin在正常大肠粘膜无表达,在大肠腺癌和腺瘤组织中表达的阳性率分别为70.9%和62.5%;大肠癌组和大肠腺瘤组OD值显著高于正常大肠粘膜组;大肠癌组中PCNA-LI为(50.2±13.2)%,显著高于正常大肠粘膜组(12.6±3.1)%和大肠腺瘤组(33.2±7.9)%;大肠癌组中Survivin阳性的PCNA-LI为(61.3±9.3)%,显著高于Survivin阴性的PCNA-LI(36.4±6.6)%。结论:Survivin和PCNA的高表达在大肠癌的发生、发展中起重要作用,PCNA可反映大肠癌的增殖状况,两者可作为判断其预后的参考指标。
Objective：To investigate the expression and significance of survivin and PCNA in colorectal carcinoma. Methods： The expression of survivin and PCNA in normal mucosa, colorectal adenoma and adenocarcinoma were detected by immunohistochemical method. Results： Survivin had no expression in the tissue of normal colorectal mucosa. The positive rates of survivin were 70. 9% and 62. 5% in colorectal adenocarcinoma and adenoma respectively. OD of survivin in colorectal adenocarcinoma and adenoma was significantly higher than in normal mucosa . PCNA-LI was 50. 2 ±13. 2 % in colorectal adenocarcinoma, which was significantly higher than in normal colorectal mt,cosa and adenoma respectively. PCNA-LI in colorectal adenocarcinoma with positive expression of st,rvivin was 61. 3±9. 3 %, Significantly higher than that with negative expression of survivin （36.4 ± 6.6%）. Conclusions： The high expression of survivin and PCNA may play an important role in the oncogenesis and development of colorectal adenocarcinoma and can be used as prognostic predictor of this tumor.
出处
《陕西医学杂志》
CAS
北大核心
2007年第11期1478-1480,共3页
Shaanxi Medical Journal
基金
陕西省教育厅专项科研计划项目(编号:05JK315)
