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(S)-1-(1-苯基乙基)-4-哌啶酮的合成 被引量：6

Synthesis of (S)-1-(1-Phenylethyl)-4-piperidone
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摘要 该文以(S)-1-苯乙胺、丙烯酸甲酯为原料,经Michael加成,Dieckmann环合,脱羧,合成了(S)-1-(1-苯基乙基)-4-哌啶酮。并对所涉及的Michael加成反应的工艺参数进行了优化。当(S)-1-苯乙胺与丙烯酸甲酯的摩尔比为1∶2.5,40℃反应10h,收率为92.4%,总收率为89.3%。目标产物及中间体的结构经核磁共振波谱进行了表征。 （S） -1-（1-Phenylethyl） -4-piperidone（ I ） was prepared from （S） -1-phenylethylamine and methyl acrylate through Michael addition, Dieckmann cyclization and decarboxylation. Technological parameters involved in Michael addition were optimized. Thus, （S） -1-phenylethylamine reacted with methyl acrylate in mole ratio 1：2.5 under 40 ℃ for 10 h to give the intermediate in 92.4% yield, and the total yield of I was 89.3%. Structures of the title compound and the intermediate were confirmed by ^1HNMR and ^13CNMR.
作者 王娟 李美玲 陈立功 李阳 闫喜龙 王东华
机构地区 天津大学药物科学与技术学院 天津大学化工学院
出处 《精细化工》 EI CAS CSCD 北大核心 2007年第11期1109-1111,共3页 Fine Chemicals
关键词 哌啶酮 MICHAEL加成 Dieckmann环合 脱羧 药物中间体 piperidone Michael addition Dieckmann cyclization decarboxylation drug intermediates
分类号 TQ460.31 [化学工程—制药化工]
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参考文献9

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二级参考文献16

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共引文献13

同被引文献22

  • 1梁诚.哌啶及其衍生物开发与应用[J].化工文摘,2004(3):30-31. 被引量：7
  • 2蒋忠良,王书玉,段辉.1-苄基-4-哌啶酮的合成研究[J].化学世界,2004,45(9):484-486. 被引量：6
  • 3韩娟,李乐平,段学民,陈立功.N-烷基-4-哌啶酮类化合物的合成[J].精细化工,2005,22(1):71-73. 被引量：11
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引证文献6

二级引证文献5

精细化工
2007年 第11期

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