摘要
目的:探讨糖尿病瘀血证的演变,为临床用药提供依据。方法:用成年雌雄各半SD大鼠82只随机分为4组:空白对照组,模型组(包括模Ⅰ,模Ⅱ,模Ⅲ)。糖尿病大鼠动物模型用STZ造模法。分别于造模成功后第7天、40天、70天处死各组大鼠,检测其舌下络脉和血液流变学指标。结果:①舌下络脉:空白组表现为正常舌象;模Ⅰ组出现瘀血舌象;模Ⅱ组瘀血舌象消失,接近正常舌象;模Ⅲ组有轻微的瘀血舌象。②血流变学:空白组各指标正常,模Ⅰ组各指标迅速升高,模Ⅱ组迅速降低,模Ⅲ组又开始升高。结论:瘀血证并未贯穿糖尿病的始终;在糖尿病初期和末期应用活血化瘀治疗,中期则无必要,这样更符合"将最安全、有效的治疗服务于患者"的循证医学的观点。
Objective： To explore the development of blood stasis syndrome of diabetes so as to provide certain scientific reference for clinical drug administration. Methods： The rat model with diabetes was induced by intraperitoneal injection of STZ. Then a total of 82 adult SD rats were randomly divided into normal group, model group Ⅰ , model groupⅡ , and model group Ⅲ. The rats were executed to check the parameter of subhngual collaterals and hemorheology at the 7th, 40th, and 70th day after the model establishment. Results： ① sublingual collaterals： Normal group showed normal conditions of the tongue ; model group Ⅰshowed blood stasis condition. In model groupⅡ , blood stasis disappeared that was close to that of the normal group, while in model group Ⅲ there was light blood stasis that was lighter than that of the model group Ⅰ. ② Hemorheology： Normal group showed normal hemorhelogical parameters. In model group Ⅰ , every parameter ascended rapidly. In model group Ⅱ, every parameter descended rapidly. The parameter ascended in model group Ⅲ. Conclusion： The blood stasis syndrome does not appear from the beginning to the end during the course of diabetes mellitus. It is necessary to apply the treatment of activating blood circulation and removing blood stasis in the first and final stage of diabetes, whereas unnecessary in middle stage.
出处
《四川中医》
北大核心
2007年第10期7-9,共3页
Journal of Sichuan of Traditional Chinese Medicine
基金
成都中医药大学针推学院科研开放基金资助(编号:10-5)
关键词
糖尿病
瘀血证
循证医学
diabetes mellitus, blood stasis syndrome, evidence- based medicine
