摘要
目的:探讨黄芪注射液在治疗系统性红斑狼疮中对外周血白细胞和免疫功能的影响。方法:选择外周血白细胞总数低于正常值的系统性红斑狼疮患者79例;随机分为常规治疗组(应用常量皮质类固醇和免疫抑制剂)和黄芪治疗组(在常规治疗的基础上加用黄芪注射液);观察和比较两组患者在治疗前后外周血白细胞、免疫球蛋白(IgG、IgA、IgM)和补体(C3、C4)的变化。结果:两组患者的外周血白细胞计数、免疫球蛋白(IgG、IgA、IgM)和补体(C3、C4)在治疗后均有不同程度的提高(P<0.05),但两组患者治疗后外周血象和免疫学指标的比较表明黄芪治疗组疗效显著优于常规治疗组(P<0.05)。结论:黄芪注射液在一定程度提高了应用皮质类固醇和免疫抑制剂治疗系统性红斑狼疮患者的疗效,可以作为提高系统性红斑狼疮疗效的重要辅助治疗措施。
Objective： To explore the effects of Radix Astragali injection on leukopenia and immune function of patients with systemic lupus erytbematosus （SLE）. Methods： A total of 79 SLE patients with lower leukocyte count were randomly assigned into routine . trestment group （ treated with routine dose of corticosteroids and immunosuppressants）, and Radix Astragali group （ treated with routine dose of corticosteroids and immunosuppressants and Radix Astragali injection）. Then this study tested and compared the change of leukocyte number, immune globulin （IgG, IgA and IgM） and complement （ C3, CA） in peripheral blood before and after the treatments. Results： The number of peripheral blood leukocytes, immune globulin and complement increased in both groups after the treatments （ P 〈0 0.05）. However, the treatment effects in the Radix Astragali group pmved much better than that in the routine treatment group （ P 〈 0.05 ）. Conclusion ： Radix Astragali injection can enhance the curative effect of corticosteroids and immunosuppressants in the treatment of SLE. It may be a valuable assistant method to enhance the efficacy of SLE treatment.
出处
《四川中医》
北大核心
2007年第11期20-21,共2页
Journal of Sichuan of Traditional Chinese Medicine
关键词
系统性红斑狼疮
黄芪注射液
外周血白细胞
免疫球蛋白
补体
systemic lupus erythematosus, Radix Astragali injection, peripheral blood leukocytes, immune globulin, complement
