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应激对老年危重患者下丘脑-垂体-甲状腺轴激素的影响 被引量:1

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摘要 目的探讨应激对老年危重患者下丘脑-垂体-甲状腺轴激素的影响。方法采用病例对照方法,选取30例老年危重患者和30例匹配的正常健康对照者,采用放射免疫法分别检测危重病患者应激状态和恢复期以及对照者的甲状腺激素和促甲状腺刺激激素水平。结果危重患者应激状态下FT_3、TT_3、TT_4、TSH水平分别低于恢复期和对照组:2.00±0.96低于3.47±0.70(P<0.01)和3.56±0.89(P<0.01)、14.14±2.31低于15.37±1.27(P<0.01)和15.64±2.36(P<0.01)、0.95±0.30低于1.45±0.39(P<0.01)和1.72±0.48(P<0.01)、59.80±24.49低于69.16+24.72(P<0.01)和71.35+20.48(P<0.01)、0.54±0.39低于1.86±0.47(P<0.01)和1.88±0.54(P<0.01),尽管FF4水平低于恢复期和对照组,但未达到统计学差异。而危重患者恢复期FT3、FT_4、TT_3、TT_4、TSH水平与对照组无统计学差异。结论危重患者下丘脑-垂体-甲状腺轴激素变化水平可作为应激状态下病情判断的重要指标。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第21期2117-2118,共2页 Chinese Journal of Gerontology
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参考文献10

  • 1廖二元,超楚生.实用内分泌学[M].第1版.北京:人民卫生出版社,2001:718-24.
  • 2杨向红,孙仁华,徐云祥,李茜.危重病患者血清甲状腺素和细胞因子变化的研究[J].中国急救医学,2003,23(1):39-40. 被引量:15
  • 3Scoscia E,Baglioni S,Eslami A,et al.Low triiodothyronine (T3) state:a predictor of outcome in respiratory failure? Results of a clinical pilot study[J].Eur J Endocrinal,2004 ;151 (5):557-60.
  • 4Vardarli I,Schmidt R,Wdowinski JM,et al.The hypothalamo-hypophyseal thyroid axis,plasma protein concentrations and the hypophyseo-gonadal axis in low T3 syndrome following acute myocardial infarct[J].Klin Wochenschr,1987 ;65 (3):129-33.
  • 5Eric Fliers,Stephan EF,Wilmar M,et al.Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness[J].J Clin Endocrinol Metab,1997 ;82(12):4032-6.
  • 6Rosen HN,Greenspan SL,Landsberg L,et al.Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency[J].Isr J Med Sci,1994;30(10):746-50.
  • 7谢秀梅,李志凌,戴田娥.充血性心力衰竭患者甲状腺激素异常变化及其临床意义(英文)[J].中国现代医学杂志,2004,14(5):42-44. 被引量:13
  • 8De Groot LJ.Non-thyroidal illness syndrome is a manifestation of hypothalamic-pituitary dysfunction,and in view of current evidence,should be treated with appropriate replacement therapies[J].Crit Care Clin,2006;22 (1):57-86.
  • 9Bartalena L.The dilemma of non-thyroidal illness syndrome:to treat or not to treat[J].J Endocrinol Invest,2003 ;26(12):1162.
  • 10Nagaya T,Fujieda M,Otsuka G,et al.A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome[J].J Clin Invest,2000 ;106(3):393-402.

二级参考文献22

  • 1[1]Mclver B,Corman CA.Enthyroid sick syndrome:an overview[J].Tyroid,1997,7(1):125-132.
  • 2[2]DeGroot LJ.Dangerous dogmas in medicine[J].Endocrinol Metab,1999,4(1):152-164.
  • 3[3]Loh.KC,Eng PC.Prevalence and prognostic relevance of sick enthyroid syndrome in a medical intensive care unit[J].Ann Acad Med Singapore,1995,24(6):802-806.
  • 4[4]Custro N,Scafidi V,Costanzo G,et al.Prospective study on thyroid function anomalies in severely ill patients[J].Ann Ital Med Int,1992,7(1):13-18.
  • 5[5]Davies PH,Black EG,Sheppard MC,et al.Relation between serum interleukin-6 and thyroid hormone concentrations in 270 hospital in-patients with non-thyroidal illness[J].Clin Endocrino,1996,44(2):199-205.
  • 6[6]Mocradian AD,Reed RL,Osterwei D,et al.Decreased serum triiodothyronine is associated with increased concentrations of tumor necrosis factor[J].J Clin Endocrinol Metab,1990,71:1239-1242.
  • 7[7]Nagaya T,Fujioda M,Otsuka G,et al.A potential role of activated NF-KB in the pathogenesis of enthyroid sick syndrome[J].J Clin Invest,2000,106(3):393-402.
  • 8[8]Gomber-Maitland M,Frishman WA.Thyroid hormone and cardiovascular disease[J].1998,135(2):187-196.
  • 9[9]Stathatos N,Lorotan C,Burman KD,et al.The controversy of the treatment of critically ill patients with thyroid hormone[J].Best Pract Res Clin Endocrinol Metab,2001,15(4):465-478.
  • 10[1]Hamilton MA,Stevenson LW,Luu M,et al.Altered thyroid hormone metabolism in advanced heart failure[J].J Am Coll Cardiol,1990,16(1):91-95.

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