摘要
探讨中华麦饭石对二甲基奶油黄诱发大鼠肝癌的预防作用。方法给Ｗｉｓｔａｒ大鼠食用含二甲基奶油黄饲料２６周诱发肝癌，同时饮用１０％中华麦饭石浸液防癌。结果实验组肝癌发生率为４１．９％，对照组达１００．０％（Ｐ＜０．００１）在８周（中毒性肝炎期）、１８周（肝脏硬变期）和２６周（肝癌期），实验组白介素┐２活性均显著高于对照组（Ｐ＜０．０５～０．００１）。辅助Ｔ细胞和抑制Ｔ细胞的比值均显著大于对照组（Ｐ＜０．０５～０．００１）。血中Ｍｎ、Ｓｉ、Ｂａ、Ｆｅ、Ｚｎ、Ｓｅ和Ｍｏ显著高于对照组（Ｐ＜０．００１），Ｃｕ和Ｃｒ显著低于对照组（Ｐ＜０．００１）。结论中华麦饭石对二甲基奶油黄诱发的大鼠肝癌有显著的预防作用。增强免疫功能和微量元素的作用可能是其预防作用的重要机制。
Objective:To find out the preventive effect of China medical stone(CMS) on DAB induced hepatocarcinoma. Methods:139 male Wistar rats were fed with DAB food and 10% CMS drinking water for 26 weeks. Results:Hepatocarcinoma incidence was 41.9%(13/31) in experimental group,but 100.0% in controls (26/26, P <0 001).The IL 2 activity,the ratio between helper T lymphocytes and suppressor T lymphocytes and the amounts of Mn、Si、Ba、Fe、Zn、Se and Mo in experiment group were all higher than those in controls( P <0 05～0 001)after tested for 3 times,but the amounts of Cu and Cr were lower( P <0 001) Conclusions:This study showed that CMS could inhibit DAB induced hepatocarcinogenesis. Enhancing immune function and the effect of trace elements may be correlated with the mechanism of CMS.
出处
《肿瘤》
CAS
CSCD
北大核心
1997年第4期209-212,共4页
Tumor
