摘要
目的探讨促红细胞生成素(EPO)对维持性血液透析(MHD)患者贫血的疗效及炎症状态对其影响。方法28例MHD患者均规范使用国产EPO(济脉欣)及常规治疗;用药前、用药后2、4、8周查血红蛋白(Hb)、红细胞压积(Hct)、网织红细胞(RCT)各1次,行自身对照;8周后Hb≥110g/L、Hct≥32%为达标组,低于此指标为非达标组;对比两组炎症反应及血清C反应蛋白(CRP)、Hb、Hct、铁蛋白(SF)变化情况。结果均在治疗2周后RCT开始上升,4周后Hb、Hct开始上升,8周上升更明显;Hb、Hct达标19例(67.85%);未达标者多有炎症存在,CRP升高,SF无差异;血浆CRP水平与Hb、Hct成负相关,与SF无相关性。结论EPO治疗肾性贫血疗效肯定;但炎症反应时CRP升高,疗效降低。
Objective To investigate the effects of national erythropoietin （EPO） treatment on maintenance hemodialysis（MHD） patients and influence of inflammation state on its effects. Methods All patients were given EPO and routine treatment. Two weeks before , and 2, 4, 8 weeks after treatment, heamoglobin （Hb）, hematocrit （Hct）, and reticulocyte （RCT） were measured . The patients were divided into two standard group（Hb≥110 g/L or Hct≥32%） and unstandard group （Hb〈110 g/L or Hct〈32%）. The changes of inflammation reaction,C-reactive protein （CRP）, Hb, Hct, serum ferritin（SF） were compared between the two groups. Results After EPO treatment for two weeks, RCT began to rise. But Hb began to rise after four weeks, obviously after eight weeks. After treatment for eight weeks and taking the same HD quantity, Hb got to the standard in 67.8% （19/28） patients. In the patients who did not get to the standard, CRP rose, which was negatively related with Hb, but not with SF. Conclusion EPO is effective in the treactment of renal anaemia. In case of inflammation state with increased CRP, the efficacy of EPO decreases.
出处
《江苏医药》
CAS
CSCD
北大核心
2007年第11期1090-1091,共2页
Jiangsu Medical Journal
基金
河北省科技厅科技攻关项目(05276101D-11)
