摘要
Graves病是以遗传为背景,在食物中的碘含量、吸烟、精神刺激及感染、药物作用、辐射暴露等环境因素作用下,诱导甲状腺自身抗原甲状腺球蛋白、促甲状腺素受体、甲状腺过氧化物酶等和自身抗体甲状腺球蛋白抗体、促甲状腺素受体抗体、甲状腺过氧化物酶抗体等在细胞毒性T淋巴细胞相关抗原-4、白介素(IL)、肿瘤坏死因子(TNF)-α、趋化因子以及黏附分子等参与下发生自身免疫反应而导致甲状腺肿大、甲状腺功能亢进的临床综合征。
Graves＇ disease is manifested by thyroid gland goiter and hyperthyroidism.It was caused by the autoantigen and their autoantibodies of thyroglobulin,thyrotropin receptor and thyroid peroxidase under the genetic background as well as environment factor such as the food iodine,smoking,spirit stimulus,infection,drug and radiation.Autoimmune reactions were happened through cytotoxicity T-lymph-cell antigen-4,interleukin,tumour necrosis factor,chemotatic factor,adhesion molecule.
出处
《国际病理科学与临床杂志》
CAS
2007年第5期438-442,共5页
Journal of International Pathology and Clinical Medicine
