摘要
目的：探讨先天性心脏病（先心病）合并肺动脉高压患儿围术期血浆内皮素浓度动态变化规律及血浆内皮素浓度与肺动脉压力关系。方法：用放射免疫法对２０例先心病患儿围术期血浆内皮素浓度进行测定，用直线相关法分析血浆内皮素浓度与肺动脉压力之间关系。结果：肺动脉高压组术前血浆内皮素浓度明显高于对照组，且与肺动脉压呈显著正相关，ｒ＝０．９７、Ｐ＜０．０１。体外循环期间，血浆内皮素浓度逐渐升高，体外循环结束时达高峰，术后逐渐下降，但肺动脉高压组术后３天血浆内皮素浓度仍高于术前。结论：血浆内皮素在肺动脉高压形成、发展过程中起一定作用，心脏直视手术过程中血浆内皮素浓度升高与体外循环密切相关。
Objective:To elucidate the periopertive variation of plasma endothelin (ET) in patients of congenital heart disease with pulmonery hypertension (PH) and the relationship between PH and ET. Methods:Twenty patients of congenital atrial or ventricular septal defect were divided into 2 groups;Group 1,with PH ( n =10);group 2 as control,without PH ( n =10).The concentration of plamsa ET was measured by radioimmunoassay.The regressive curve of plasma ET and PH was plotted and the correlative coefficient was calculated. Results:The level of plasma ET in PH group was higher than in control group before operation and correlated positively with pulmonary pressure ( r =0 97, p <0 01).The concentration of plasma ET increased continually during cardiopulmonary bypass (CPB) and peaked at the end of CPB and was still higher than the preoperative level on the 3rd day after operation. Conclusion:Plasma ET plays a certain role in the formation and developmant of PH.The elevation of plasma ET is closely related to CPB during open heart surgery.
出处
《中国循环杂志》
CSCD
北大核心
1997年第4期293-295,共3页
Chinese Circulation Journal
基金
河北省科委计划
