摘要
本实验随机将家兔一侧后肢于膝关节伸直位夹板外固定５周，制成固定侧胫骨上端骨内高压模型。对其全身和局部血液流变学指标进行测定，发现全血粘度，血浆粘度增大，血沉增快，血浆纤维蛋白原含量明显增高。对上述模型应用蝮蛇抗栓酶（ｓｖａｔｅ）连续治疗２１天，骨内压降低，血液流变学各项指标亦降低。本实验结果显示，蝮蛇抗栓酶通过改善骨内高压状态下的异常血液流变学状态可使骨内高压降低，从而认为血液流变学疗法可能成为临床治疗骨内高压症的一种新手段，而蝮蛇抗栓酶可能为其中高效药物之一。
An experimental model of intraosseous hypertension of the proximal tibia was produced by one hindlimb of rabbit immobilized with a splint on the knee in extension position for five weeks. Under this condition, the viscosity of both whole blood and plasma increased obviously, and so did the ESR and the contents of blood fibrinogen. After using SVATE for three weeks, the values of all parameters of the hemorrheologiacal test of the venous blood and intramedullary blood decreased significantly. The results showed that the SVATE was able to lower the intraosseous hypertension by means of improving hemorrheological state which further decreased the intraossous hypertension. The SVATE had a significant effect in improving the abnormal hemorrheological state. So it could become a new drug to lower the intraossous hypertension.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1997年第7期448-452,共5页
Chinese Journal of Orthopaedics
关键词
蝮蛇抗栓酶
骨内高压
血液流变学
骨病
Snake antithrombotic enzyme Intraosseous hypertension Blood viscosity Hemorrheology
