摘要
目的:认识强直性脊椎炎的多种发病假说,以明确和分析其病理机制。资料来源:应用计算机检索Pubmed数据库1994-01/2007-03有关强直性脊柱炎病理机制的文章,检索词"ankylosingspondylitis pathomechanism",限定文章语言种类为English;同时计算机检索中国期刊全文数据库2000-01/2005-04期间的相关文章,检索词"强直性脊柱炎,病理机制",限定文章语言种类为中文。资料选择:对资料进行初审,选取符合研究要求的有关文章找全文。纳入标准:有关强直性脊椎炎病理机制的研究(包括基础研究和临床研究)。排除标准:重复或类似的同一研究、综述文献(或个案报道等)。资料提炼:共收集到65篇有关强直性脊椎炎病理机制的文章,排除重复或类似的同一研究,30篇符合综述要求。资料综合:①国内有关强直性脊椎炎病理机制的研究:就强直性脊椎炎患者外周血液及关节液中的某个因子在遗传、免疫等方面的易感性表达,进行相关分析。②国外有关强直性脊椎炎病理机制研究:在分子生物学及遗传免疫学领域,就某个易感因子提出"基因"的关联假说。③强直性脊椎炎病理机制研究展望:针对强直性脊椎炎病理机制,在细胞通讯与细胞信号转导的分子机制方面进行研究。结论:强直性脊柱炎是环境因素与遗传因素共同作用的结果,环境因素是发病的诱因,遗传的易感性是强直性脊柱炎发病的基础,其中,人类白细胞抗原B27的未折叠蛋白应答是核心。强直性脊椎炎的病理机制存在以"免疫应答为开始、信号转导为过程、基因易感为结果"的轴心系统。
OBJECTIVE： To know various morbidity hypotheses about ankylosingspondylitis, so as to identify pathomechanism. DATA
SOURCES： A computer-based online search of Pubmed was undertaken to identify the articles concerned with pathomechanism of ankylosingspondylitis dated from January 1994 to March 2007 with the keywords of ＂ankylosingspondylitis, pathomechanism＂. Meanwhile, we searched Chinese Journal Full-text Database for related Chinese articles published from January 2000 to April 2005 with the same keywords in Chinese.
STUDY SELECTION： The data were firstly selected to choose the articles met the requirement, and the full-text was looked over. Only articles about the pathomechanism of ankylosingspondylitis were selected including basic research and clinical research, and repetitive or analogical researches, review articles or case reports were excluded.
DATA EXTRACTION： Totally 65 related articles were collected, and after eliminating the repetitive or similar studies, 30 articles were included. DATA SYNTHESIS： ① In the domestic studies on the pathomechanism of ankylosingspondylitis, the susceptible expression of certain factor in the peripheral blood and synovial fluid of ankylosingspondylitic patients on heredity and immunization are analyzed. ②In the abroad study about pathomechanism of ankylosingspondylitis, the gene correlated hypothesis is proposed concerning certain susceptible factor on molecular biology, and hereditary immunity domains. The future studies on the pathomechanism of ankylosingspondylitis mainly concern on intercellular communication and signal transduction molecule mechanisms.
CONCLUSION： Ankylosingspondylitis is the common effect of environmental factor and genetic factor; environmental factor is motivation, and genetic sensitivity is foundation, in which the unfoled protein about human leucocyte antigen-B27 is the core. Immune respond to signal transduction and gene sensitivity is the core system of the pathomechanism of ankylosingspondylitis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第45期9176-9181,共6页
Journal of Clinical Rehabilitative Tissue Engineering Research
