期刊文献+

建立移植型肺癌动物模型的最新方法和进展 被引量:2

下载PDF
导出
摘要 在众多的肺癌模型研究中,尤其是移植型肺癌模型,是将人肺癌细胞移植到动物体内传代生长,其移植的肿瘤细胞形态学特征,染色体数量,同工酶水平等仍保持不变,对临床常用抗癌药物敏感性也大致相同,所以常用来做疾病定向性筛选,抗癌药物的筛选。同时还具有移植肿瘤细胞生长迅速,倍增时间短,耗费低等优点。
出处 《重庆医科大学学报》 CAS CSCD 2007年第12期1337-1339,共3页 Journal of Chongqing Medical University
  • 相关文献

参考文献20

  • 1Kelland LR. Of mice and men:values and liabilities of the athymic nude mouse model in anticancer drug development [J]. European Journal Of Cancer, 2004 ;40(6) : 827-836.
  • 2彭鹏,杜秀平.肺癌动物模型的制作概况[J].徐州医学院学报,2005,25(3):263-267. 被引量:5
  • 3Welch DR. Technical considerations for studying cancer metastasis in vivo[J]. Clinical and Experimental Metastasis,1997;15(3): 272-306.
  • 4March TH, Marron-Terada PG,Belinsky SA. Refinement of an orthotopic lung cancer model in the nude rat[J]. Veterinary Pathology, 2001 ; 38 (5) :483-490.
  • 5Tanaka E,Yamashita J,Hayashi N,et al. A Pulmonary Metastatic Model of Human Non-small Cell Lung Carcinoma Cells That Produce a Neutrophil Elastase-Like Molecule in Severe Combined Immunodeficiency Mice[J]. Laboratory and Animal Investigations,2003; 123(4) : 1248-1253.
  • 6Arenberg DA,Zlotnick A,Strom SR,et al. The murine CC chemokine,6C-kine,inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model[J]. Cancer Immunol Immunother, 2001 ;49( 11 ) : 587-592.
  • 7Kitamura H,Tsubakihara M,Inayama Y,et al. Long-term maintenance of human distal airway epithelial cells in nude mice: a potentially useful model for the study of pulmonary carcinogenesis and lung cell biology[J]. Laboratory Investigation;A Journal Of Technical Methods And Pathology, 1990; 62 (3) : 383-389.
  • 8Ahrar K, Madoff DC, Gupta S,et al. Development of a large animal model for lung tumors[J]. Journal Of Vascular And Interventional Radiology:JVIR,2002; 13( 1 ) :923-928.
  • 9薛强,屈谦,杜永洪,李崇雁,文爽,曹友德,范炜,白晋,伍烽,王智彪.兔VX_2肺癌模型的建立及生物学特性观察[J].中华实验外科杂志,2001,18(5):478-478. 被引量:14
  • 10Howard RB,Mullen JB,Pagura ME,et al. Characterization of a highly metastatic,orthotopic lung cancer model in the nude rat[J]. Clinical and Experimental Metastasis, 1999; 17(2): 157-162.

二级参考文献24

  • 1魏泓,牛荣,黄中波,吴丰春,邢瑞昌.人肺癌不同程度免疫缺陷小鼠的移植及其高转移模型的建立[J].中国实验动物学杂志,1997,7(2):107-111. 被引量:7
  • 2Pfister DG, Johnson DH, Azzoli CG, et al. American soiety of clinical oncology treatment of unresectable NSCLC GUiDELINe: Update 2003[J] .J Clin Oneol,2004,22(2):330- 353.
  • 3Malkinson AM. Primary lung turrets in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung[J].Lung Cancer, 2001,32(3) :265 - 279.
  • 4Wang HY, Ross HM, Ng B, et al. Establishment of an experimental intrapulmonary tumor nodule model[J]. Ann Thorac Surg, 1997,64( 1 ) :216 - 219.
  • 5Pepelko WE, Chen C. Quantitative assessment of cancer risk from exposure to diesl engine emissions[J]. Regul Toxicol Pharmacol,1993, 17(1):52-65.
  • 6Mercer RR, Russell ML, Crapo JD. Randon dosimetry based on the depth distribution of nuclei in human and rat lungs[J]. Health Phys,1991,61(1):117- 130.
  • 7Lubet RA, Zhang Z, Wang Y, et al. Chemoprevention of lung cancer in transgenic mice[J]. Chest,2004,125(5 Suool) : 144s - 147s.
  • 8MacEwen EG. Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment [ J ]. Cancer metastasis Rev,1990,9(2) : 125 - 136.
  • 9Heinrich U, Roller M, Pott F. Estimation of a lifetime unit lung cancer risk for benzo (a) pyrene based on tumour rates in rats exposed to coal tar/pitch condensation aerosol [J].Toxicol Lett, 1994,72( 1 - 3 ) : 155- 161.
  • 10Flora S, lzzotti A, Agostini F, et al. Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice[J]. Exp Lung Res,2005,31(1) :19- 35.

共引文献17

同被引文献14

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部