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VEGF-C调控机制研究进展 被引量：2

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摘要 肿瘤的新生淋巴管形成参与肿瘤的增生、侵袭和肿瘤细胞向远处转移等多种恶性过程。血管内皮生长因子C（vascular endothelial growth factor-C VEGF—C）是已知的主要淋巴管形成生长因子，它通过对肿瘤间质新生淋巴管内皮细胞的增殖和迁移的调控，促进肿瘤的淋巴管形成。其在肿瘤局部浸润、远处转移过程中起着重要作用，研究VEGF—C的调控因子对于肿瘤的病理学研究和临床肿瘤防治有重要作用。
作者 龚宇 胡国华
机构地区 重庆医科大学附属第一医院耳鼻喉科
出处 《重庆医科大学学报》 CAS CSCD 2007年第12期1353-1356,共4页 Journal of Chongqing Medical University
基金 重庆市自然基金(2006BB5294) 重庆市卫生局基金(072070)
关键词 VEGF 调控因子 血管内皮生长因子 淋巴管形成 淋巴管内皮细胞 肿瘤细胞 远处转移 肿瘤间质
分类号 R735.7 [医药卫生—肿瘤]
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  • 1Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals..Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases[J].World Journal of Gastroenterology,2001,7(3):381-386. 被引量：19
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  • 6Jeltsh M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels VEGF-C transgenic mice[J]. Science, 1997,276(5317):1423-1425.
  • 7Welsh CL, Welsh M, Ito N, et al. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD[J]. Proc Natl Acad Sci USA, 1998,95(10): 5579-5583.
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  • 10Mattila MM, Ruohola JK, Karpanen T, et al. VEGF-C induced lyphangiogenesis is associated with node metastasis in orthotopic MCCF7 tumors[J]. Int J Cancer, 2002,98(6) :946-951.

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重庆医科大学学报
2007年 第12期

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