摘要
目的:通过动物实验观察消炎液对肢体动脉缺血性疾病的治疗作用。方法:造模成功后,将30只大白鼠随机分为空白对照组、生理盐水组和消炎液治疗组,每组10只,分别给予不同的处理,于第21天处死动物取标本进行病理检查、检测VEGF水平以及平均血管密度。结果:消炎液组与对照组比较,肢端坏疽、感染范围明显减小,同时患肢跛行和肿胀减轻,且消炎液组VEGF和FⅧ相关抗原的表达水平高于对照组(P<0.05)。结论:消炎液可以有效的防止坏疽肢端和缺血肢体的局部组织坏死液化后继发感染,在一定程度上缓解肢体疼痛;并促进患肢侧支循环的建立,从而减少截肢的范围。
Objective： To research the effect of Antiphlogistic Liquid used in Hind Limb Ischemia rats, and to approach the mechanism. Methods： 30 rats were divided into three groups： blank groups （10）,NS groups （10） and Antiphlogistic Liquid groups （10）. Different treatment were provideed. On 7th day,14th day and 21th day after the operation, the limbs were observed. After 21 days, sacrificed all rats, took the organization specimen.The expression of VEGF in protein level and average blood vessel densities were identified.Results： After Antiphlogistic Liquid was used, the ambit of gangrene and the infection was decreased. At the same time the limp and swelling was relieved. What＇s more, accompanied with the VEGF and F Ⅶ related antigen expression increament, the collateral circulation was established. Conclusion： Antiphlogistic Liquid can effectively prevent the the gangrene and the local tissue of the ischemia limb from seconddory infecton, and realease the ache of the affected limbs. In a way, the Antiphlogistic Liquid can release the ache of the attected limb and prompt the establishement of the compensatory circulation. As a reault the Antiphlogistic Liquid can diminish the extent of amputated extremity.
出处
《中国现代普通外科进展》
CAS
2007年第5期386-388,共3页
Chinese Journal of Current Advances in General Surgery
