摘要
脑梗死不仅是局部损伤,而且还会引起远隔缺血部位的继发性损伤,这种继发性损伤会阻碍神经功能的恢复。Ephrin B2受体(EphB2)在中枢神经系统发育和修复机制中起着重要作用。利用特异性抑制剂阻断脑内EphB2的作用,能促进实验性脑梗死后内源性神经干细胞增殖和迁移,改善神经功能,并可能影响远隔部位血管发生和神经可塑性,有望成为减轻脑梗死远隔部位损伤和促进神经功能恢复的新途径。
Cerebral infarction is not only a focal damage, but also causes secondary damage in areas remote from the ischemic territoryrin receptor B2 （EphB2） pla, which will retard the recovery of neurological function. Ephys an important role in the development and repair mechanism of central nervous system. Blocking the effect of EphB2 in brain by using a specific inhibitor may enhance proliferation and migration of endogeneous neuronal stem cells after experimental cerebral infarction, imporove neurological function and influence angiogenesis and neuroplasticity in remote sites. It is expected to become a new approach for decreasing damages in areas remote from the cerebral infarction and promoting the recovery of neurological function.
出处
《国际脑血管病杂志》
2007年第10期790-792,共3页
International Journal of Cerebrovascular Diseases
