摘要
用含硒（Ｓｅ０．５ｍｇ／ｋｇ）和／或维生素Ｅ（ＶＥ０．６ｇ／ｋｇ）的高脂饲料喂养成年雄性Ｗｉｓｔａｒ大鼠１２周。结果：高脂对照组大鼠血浆前列腺素Ｆｌα（６－酮－ＰＧＦ１α）水平下降，而血清脂质过氧化物（ＬＰＯ）、血浆血栓素（ＴＸＢ２）及内皮素（ＥＴ）水平上升；补Ｓｅ、ＶＥ及Ｓｅ＋ＶＥ可明显降低大鼠血清ＬＰＯ、血浆ＴＸＢ２、ＥＴ及ＴＸＢ２／６－酮－ＰＧＦ１α比值。同时，除了明显提高血浆谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力外，血浆６－酮－ＰＧＦ１α浓度明显升高。实验提示，Ｓｅ和／或ＶＥ有调节花生四烯酸代谢及保护内皮细胞的作用。
The preventive effect of selenium and/or vitamin E on productions of prostacyclin F 1α (6 keto PGF 1α )、thromboxane B 2(TXB 2),as well as TXB 2/6 keto PGF 1α ,endothelin(ET)were investigated in experimental hyperlipidemic Wistar rats fed high fat diets(HFD)containing Se(0.5mg/kg)and/or VE(0.6g/kg)for 12 weeks.The results showed that plasma level of 6 keto PGF 1α of rats fed with HFD was decreased,while lipid peroxides(LPO),TXB 2,ET and TXB 2/6 keto PGF 1α ratio were increased.The production of LPO,TXB 2,ET and TXB 2/6 keto PGF 1α was reduced significantly in rats maintained on Se and/or VE supplemented diets,meanwhile 6 keto PGF 1α level together with activity of plsama glutathione peroxidase(GSH Px)were increased significantly.This study indicated that Se and/or VE supplementation might modulate arachidonic acid metabolism in hyperlipidemic rats.
出处
《营养学报》
CAS
CSCD
北大核心
1997年第2期163-166,共4页
Acta Nutrimenta Sinica
基金
研究生科研经费资助
关键词
硒
维生素E
前列腺素
血栓素
内皮素
冠心病
selenium vitamin E prostacyclin F 1α thromboxane B 2 endothelin
