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蛋白质微阵列的制备及其在病原体检测中的应用

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摘要 蛋白质微阵列是近年发展起来的新技术,具有高通量、微型化及自动化等优点,能够高通量地测定蛋白质的存在及其生物活性,也可以测定蛋白质与生物大分子之间的相互作用。本文介绍了蛋白质微阵列的制备方法及其在病原体毒力、耐药性及免疫原性等方面的应用。
作者 庞靖祥 韩金祥 高雪芹
机构地区 山东省医药生物技术研究中心卫生部生物技术药物重点实验室
出处 《中国生物制品学杂志》 CAS CSCD 2007年第10期783-785,共3页 Chinese Journal of Biologicals
基金 山东省科技攻关计划资助课题(2004GG2202150)
关键词 蛋白质微阵列 病原体 毒力 耐药性 免疫原性
分类号 R392.33 [医药卫生—免疫学]
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参考文献20

  • 1Templin MF,Stoll D,Schrenk M,et al.Protein microarray technology.Trends Biotechnol,2002,20(4):160-166.
  • 2He ZG,Zhong H,Hu YH,et al.Analysis of differential protein expression in Acidithiobacillus ferrooxidans grown under different energy resources respectively using SELDI-ProteinChip technologies.JMicrobiol Methods,2006,65(1):10-20.
  • 3Kim M,Jung SO,Park K,et al.Detection of Bax protein conformational change using a surface plasmon resonance imaging-based antibody chip.Biochem Biophys Res Commun,2005,338 (4):1834-1838.
  • 4Espina V,Woodhouse EC,Wulfkuhle J,et al.Protein microarray detection strategies:focus on direct detection technologies.J Immunol Methods,2004,290(1-2):121-133.
  • 5Sauer U,Preininger C,Krumpel G,et al.Kern.Signal enhancement of protein chips.J Sensors Actuators B:Chemical,2005,107 (1):178-183.
  • 6Hu CY,Chang YJ,Yin LT,et al.Optimal design of nickel-coated protein chips using Taguchi approach.J Sensors Actuators B:Chemical,2005,108(1-2):665-670.
  • 7Kim JW,Yamagata Y,Takaskai M,et al.A device for fabricating protein chips by using a surface acoustic wave atomizer and electrostatic deposition.J Sensors Actuators B:Chemical,2005,107(2):535 -545.
  • 8Jung WL,Sang JS,Sung MC,et al.Characterization of a self-assembled monolayer of thiol on a gold surface and the fabrication of a biosensor chip based on surface plasmon resonance for detecting antiGAD antibody.Biosensors Bioelectron,2005,20(7):1422-1427.
  • 9Ramachandran N,Hainsworth F,Bhullar B,et al.Self-assembling protein microarrays,Science,2004,305(5680):86-90.
  • 10Combaret V,Bergeron C,Bréjon S,et al.Protein chip array profiling analysis of sera from neuroblastoma patients.Cancer Let,2005,228(1-2):91-96.

二级参考文献17

  • 1闫实,韩金祥,高雪芹,黄海燕,马荣,赵连英.用肿瘤转移基因芯片筛查乳腺癌转移相关基因表达谱[J].山东大学学报（医学版）,2004,42(3):269-273. 被引量：5
  • 2Sanders GHW, Manz A. Chip-based Microsystems for genonfic and proteomic analysis. Trends Anal Chem, 2000,19(6) : 364-378.
  • 3Lueking A, Horn M, Eickhoff H, et al. Protein microarrays for gene expression and antibody screening. Anal Biochem, 1999, 270( 1 ) : 103-111.
  • 4MacBeath G, Schreiber SL. Printing protein as microarrays for high-throughput function determinatiun. Science, 2000, 289 ( 5485 ) : 1760-1763.
  • 5Holt LJ, Bussow K, Walter G, et al. By-passing selection: direct screening for antibody-antigen interactions using protein arrays. Nucleic Acids Res, 2000, 28(15): E72.
  • 6Uetz P, Giot L, Cagney G, et al. A comprehensive analysis of protein interactions in Saccharomyces cerevisiae. Nature, 2000, 403 (6770):623-627.
  • 7Senior K. Fingerprinting disease with protein chip array. Mol Med Today 1999, 5(8): 326-327.
  • 8Rowe CA, Scruggs SB, Feldstein MJ. An array immunosensor for simultaneous detections of clinical analytes. Anal Chem, 1999, 71 (2) : 433-439.
  • 9Rowe CA, Tender LM, Feldstem MJ. Array biosensor for simultaneous identification of bacterial, viral and protein analytes. Anal Chem, 1999,71 ( 17 ) : 3846-3852.
  • 10Cunningham MJ. Genomics and proteomics: The new millennium of drug discovery and development. J Pharmacol Toxicol Methods, 2000, 44( 1 ) : 291-300.

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中国生物制品学杂志
2007年 第10期

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