摘要
目的:探讨术前新辅助化疗对局部晚期宫颈癌治疗的疗效。方法:以40例Ⅰb～Ⅱb期局部晚期宫颈癌患者为实验组,予顺铂、丝裂霉素、氟尿嘧啶化疗1～2个疗程,随后行根治性手术;以31例同期同条件直接给予根治性手术的患者为对照组,随访3年,比较两组患者的淋巴结转移率、复发率及生存时间。结果:实验组患者化疗有效率为70.00%,实验组患者的淋巴结转移率及复发率均显著低于对照组(P值均<0.05);实验组患者的无瘤生存时间及术后生存时间则显著长于对照组(P=0.0136,P=0.0108)。实验组患者中化疗有效者的淋巴结转移率及复发率均显著低于化疗无效者(P值均<0.05);化疗有效者的无瘤生存时间及术后生存时间则显著长于化疗无效者(P=0.0116,P=0.0172)。结论:局部晚期宫颈癌术前新辅助化疗可缩小肿瘤体积、降低淋巴结转移率及复发率、延长患者生存时间,是有效的治疗方法。PMF方案是术前新辅助化疗的有效方案。
Objective： To determine the effects of neoadjuvant chemotherapy on locally advanced cervical cancer. Methods： Forty patients with locally advanced stage Ⅰb and Ⅱb cervical cancer were chosen for the experimental group. They received 1 to 2 courses of treatment consisting of cisplatin, mitomycin and fluorouracil. After the chemotherapy regimen was completed, the patients underwent radical surgery. A group of 31 cases with the same diagnoses received radical surgery alone. This group was considered the control group. The patients were followed for 3 years. The rate of lymph node metastasis, the rate of recurrence and the survival time were compared between the two groups. Results： The effective rate of chemotherapy for patients in the experimental group was 70.00%. In that group, the rate of pelvic lymph node metastasis and relapse rate were significantly lower compared to the control group （P〈0.05, P〈0.05）. The tumor-free time and the postoperative survival time in patients of the experimental group were also significantly longer compared to the controls （P=0.0136, P=0.0108）. The lymph node metastasis rate and relapse rate were significantly lower for patients in the experimental group who responded well to the chemotherapy compared to those patients in the experimental group who did not respond well to the treatment （P〈0.05, P〈0.05）. The tumor-free time and the postoperative survival time of the patients in the experimental group who responded well to the treatment were also significantly longer than those with a poor response （P=0.0116, P=0.0172）. Conclusion： Neoadjuvant chemotherapy is beneficial for diminishing gross tumor volume, reducing the rate of lymph node metastasis and relapse, and prolonging the survival time of patients with locally advanced cervical cancer. The PMF regimen is effective in the treatment of locally advanced cervical cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第4期226-229,共4页
Chinese Journal of Clinical Oncology
关键词
新辅助化疗
宫颈癌
顺铂
丝裂霉素
氟尿嘧啶
Cervical cancer Neoadjuvant chemotherapy Cisplatin MitomycinC Fluorouracil
