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急性乙醇性胃黏膜损伤中三磷酸腺苷合成酶6和8亚基的表达 被引量:1

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摘要 乙醇是导致胃黏膜损伤的一个常见因素,它可通过多种机制损伤胃黏膜,氧自由基(oxygen free radical,OFR)对胃黏膜的氧化应激作用是其中的一个重要方面。线粒体是细胞内最易受乙醇作用而损伤的细胞器,其中线粒体DNA(mitochondrial,mtDNA)又是细胞内乙醇相关氧化应激的主要目标。mtDNA三磷酸腺苷(ATP)合成酶6和8基因表达产物ATP合成酶6和8蛋白是ATP合成酶F。部分的两个组分,通过调控质子转运而调节ATP合成,决定细胞内ATP的含量。在乙醇引起的胃黏膜损伤中,氧自由基是否影响mtDNAATP合成酶的表达,干扰胃黏膜细胞能量代谢尚不清楚。本研究采用乙醇灌胃制备急性胃黏膜损伤动物模型,旨在探讨氧自由基和能量代谢调控基因在急性乙醇性胃黏膜损伤中的作用。
出处 《中华消化杂志》 CAS CSCD 北大核心 2007年第11期782-783,共2页 Chinese Journal of Digestion
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