摘要
目的评价厄贝沙坦与小剂量胺碘酮联合治疗心功能正常的阵发性房颤的长期疗效。方法将142例阵发性房颤随机分为胺碘酮组(n=72)、胺碘酮+厄贝沙坦组(n=72),治疗随访时间为18个月,研究的一级终点为房颤复发,比较两组治疗后窦性心律的维持率以及治疗前后6、12、18个月左心房内径。结果治疗12个月后,胺碘酮组左心房内径大于胺碘酮联合厄贝沙坦组(P<0.05)。试验终点时单用胺碘酮组窦性心律维持率为58.04%,联合用药组为84.06%,两组比较差异有统计学意义(P<0.05)。结论胺碘酮联合厄贝沙坦在维持窦性心律作用优于胺碘酮,且能抑制左心房的扩大。
Objective To evaluate effects of irbesartan and low dose amiodarone in patinets with paroxysmal atrial fibrillation who had normal heart function,and long-term therapeutic effect of maintain sinus rhythm. Methods A total of 142 patinets with paroxysmal atrial fibrillation were divided into two groups randomly： amiodarone group（ n = 72）,irbesartan and amiodarone group （n = 72）, term of follow-up was 18 months. First class end point was atrial fibrillation recrudescence. The post-treatment rate of maintain sinus rhythm,and inner diameter of left auricle at pretherapy and post-treatment for 6,12,18 months with amiodarone group and irbesartan and amiodarone group were compared. Results After treatment for 12 months,inner diameter of left auricle in amiodarone group exceeded irbesartan and amiodarone group（P〈0.05）. At end point,sustain rate of sinus rhythm in amiodarone group was 58.04 % ,and that of combination medication group was 84.06 %, there was significant difference between two groups（P〈0.05）. Conclusion Irbesartan and amiodarone surpassed amiodarone in sustaining rate of sinus rhythm and inhibited left auricle enlargement.
出处
《中国基层医药》
CAS
2007年第10期1622-1623,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心房颤动
胺碘酮
厄贝沙坦
Atrial fibrillation
Amiodarone
Irbesartan
