摘要
目的：探讨新生儿先天性甲状腺功能低下症（CH）与不同出生体重及胎龄的关系。方法：对浙江省2005年活产婴儿进行CH筛查。采用时间分辨荧光免疫方法，检测新生儿足跟血斑的促甲状腺素（TSH）指标。凡滤纸血TSH〉9．0mIU／L者予以召回，进行甲状腺功能等检查。结果：2005年共筛查新生儿387926人，确诊CH病例289人，CH发病率为1／1342。其中，早产儿（胎龄〈37周）CH发病率为1／1454，足月儿（胎龄37～42周）为1／1469，过期产儿（胎龄〉42周）为1／246；过期产儿CH发病率明显高于另外两组儿童（P〈0．01）。在低出生体重儿童中，CH发病率为1／575，正常体重组儿童发病率为1／1505，而巨大儿发病率为1／473，低出生体重儿童及巨大儿的CH发病率明显高于正常体重组儿童（P〈0．01）。结论：CH的发病与新生儿出生时的体重、胎龄等因素有关。过期产儿、低出生体重、巨大儿的新生儿CH的发病率最高；因此，防止过期产、减少低出生体重和巨大儿的出生、注意孕期保健是减少CH儿童的关键，这对于降低CH发病率，提高出生人口素质有着积极的意义。
Objective. To investigate the correlation of congenital hypothyroidism （CH） with birth weight and gestational age in newborn infants. Methods. The screening of CH was conducted in all the live births in 2005 of Zhejiang Province, the blood samples were collected from heel stick. The thyroid stimulating hormone （TSH） was measured by time-resolved fluorescence immunoassay （TRFIA）. If TSH was〉9.0 mU/L,the infant was recalled for further examination. Results： A total of 387 926 infants were screened in 2005,of whom 289 cases were identified with CH. The prevalence rate was 1/1 342. Among the 289 CH cases,the prevalence of premature infants, term infants and post term infants were 1/1 454, 1/1 469 and 1/246, respectively. The CH prevalence of post term infants was significantly higher than that in other two groups （P〈0.01）. The prevalence of low birth weight infants,normal weight infants and macrosomia was 1/575, 1/1 505 and 1/473, respectively. The prevalence of low birth weight infants and macrosomia was significantly higher than that of normal weight group（P〈0.01）. Conclusion： The prevalence of CH is associated with the birth weight and gestational age. To reduce the prevalence of CH in children,it is crucial to prevent post term,low birth weight,and macrosomia cases.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2007年第4期378-381,共4页
Journal of Zhejiang University(Medical Sciences)
基金
浙江省科技厅科研基金重点项目(021107597)
