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氯吡格雷改善高血压病高危患者阿司匹林抵抗的临床研究 被引量：2

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摘要 目的研究氯吡格雷对高血压病高危阿司匹林抵抗患者的治疗价值。方法525例高血压病高危患者依照血小板聚集率分为阿司匹林敏感者和阿司匹林抵抗者,将114例阿司匹林抵抗者随机分为单用阿司匹林治疗组和氯吡格雷联合阿司匹林治疗组,411例阿司匹林敏感者中随机选取40例设为对照组。三组患者给予严格的药物治疗后随访一年,观察阿司匹林治疗组和联合治疗组患者在治疗前后的血小板聚集率变化,以及三组患者治疗后缺血性心脑血管病的发生率和出血性事件的发生率。结果氯吡格雷可以有效地降低阿司匹林抵抗患者的血小板聚集率(P<0.01);较少发生缺血性心脑血管病(P<0.01),而不增加出血事件的发生(P>0.05)。结论氯吡格雷与阿司匹林联用安全,且能提高阿司匹林抵抗患者的临床疗效。
作者 张永胜 刘毅坚
机构地区 晋城煤业集团总医院
出处 《临床内科杂志》 CAS 2007年第11期771-772,共2页 Journal of Clinical Internal Medicine
关键词 高血压病 氯吡格雷 阿司匹林抵抗
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献8

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同被引文献14

  • 1赵卓,吴学思,韩智红,吕强,胡荣,马长生.不稳定性心绞痛患者住院早期应用不同剂量普伐他汀的临床研究[J].中华心血管病杂志,2005,33(1):54-57. 被引量：55
  • 2韩文忠,郭华,杨宝刚.阿司匹林、氯吡格雷对冠心病心力衰竭治疗的影响[J].中国医药,2006,1(3):138-139. 被引量：15
  • 3Bueh AN,Singh S,Roy P,et al. Measuring aspirin resistance,elopidogrel responsiveness and postprocedural markers ofmyonecrosis in patients undergoing pereutaneous corunaryinterventiun[ J]. Am J Cardiol,2007,99(ll) :1518.
  • 4颜红兵,马长生,霍勇,等.美国不稳定心绞痛和非ST段升高心肌梗死治疗指南[M].中国环境科学出版社,2007.78.
  • 5陆再英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008:775.
  • 6Gum PA, Kottke-Marchant K, Poggio ED, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease[J]. Am J Cardiol, 2001, 88(3):230-235.
  • 7Papathanasiou A, Goudevenos J, Tselepis AD. Aspirin resistance in cardiovascular disease:pathogenesis, diagnosis and clinical impact [J]. Curr Pharm Des, 2009, 15(10): 1085-1094.
  • 8Jneid H, Bhatt D, Corti R, et al. Aspirin and clopidogrel in acute coronary syndromes:therapeutic insights from the CURE study[J]. Arch Intern Med, 2003, 163(10):1145-1153.
  • 9Krauss T, Emons G, Kuhn W, et al. Predictive value of routine circulating soluble endothelial cell adhesion mol- ecule measurements during pregnancy[J]. Clin Chem, 2002, 48(9): 1418-1425.
  • 10魏述建,陈玉国,张运.阿司匹林和氯吡格雷抵抗的研究进展[J].心血管病学进展,2008,29(6):946-949. 被引量：10

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临床内科杂志
2007年 第11期

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