摘要
为了探讨幽门螺旋杆菌（HeliclbacterPylori，HP）感染与胃癌发生间的关系，我们采用免疫组化法对158例胃粘膜标本进行癌基因c－myc、c－erbB－2蛋白检测、其中胃癌、不典型增生及肠上皮化生各40例，正常对照38例。结果发现，c－myc蛋白在正常胃组织中无表过，c－erbB－2蛋白阳性表达7／38例。两种基因蛋白在不典型增生、肠上皮化生及胃癌中的阳性表达显著高于对照组（P＜0．01～0．05）。应用Giemsa法对上述各组胃粘膜同步进行HP测定，发现正常对照组中的HP阳性检出显著低于不典型增生及肠上皮化生（P＜0．025），而与胃癌组无明显统计学差异（P＞0．05）。联合检测HP与癌基因蛋白发现HP感染与其表达呈正相关。提示HP感染与胃癌发生有一定关系。
Oncogene c-myc. c-erbB-2 proteins were determined immunohistochemically in 158 gastric mucosa specimens to study the relation between HP infectionand the formation of gastric cancer. This series consisted of gastric cancer in 40 cases,atypical hyperplasia 40, intestinal metaplasia 40 and normal control 38. The resultsshowed that no c-myc protein was expressed in normal gastric mucosa .while expressionof c-erbB-2 was observed in 7/38 cases. The expression of these two gene proteins inthe atypical hyperplasia, intestinal metaplasia and gastric cancer groups were significantly higher than in the control (P＜0.01～0.05). Detection of HP in all the cases withGiemsa staming revealed that the positive rate of the control group was significantlylower than those in the atypical hyperplasia and intestinal metaplasia groups (P＜0.025 ) but no significant statistic difference was observed between the control groupand the gastric cancer group (P＞0.05). Combined determination of HP and oncogeneproteins disclosed a positive correlation between them. The study suggests that HP infection is related to the generation of gastric cancer to a certain extent.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第7期516-519,共4页
Chinese Journal of Clinical Oncology
